Title:
A manufacturing method of fluoride 18 sign full Mazeniru using a diaryliodonium salt precursor
Document Type and Number:
Japanese Patent JP6035328
Kind Code:
B2
Abstract:
Disclosed is the synthesis of [ 18 F]flumazenil that is useful in imaging epileptic lesions by PET (positron emission tomography). A method for preparing [ 18 F]flumazenil by reacting a diaryliodonium salt precursor with the positron-emitting radionuclide fluorine-18. [ 18 F]flumazenil can be prepared from the diaryliodonium salt precursor in the presence of kryptofix 2.2.2. /potassium carbonate(K 2.2.2. /K 2 CO 3 ) and TEMPO in dimethylformamide (DMF) at a high yield.
Inventors:
Lee, Byung Chung
Byun Suk
Kim jison
Byun Suk
Kim jison
Application Number:
JP2014512742A
Publication Date:
November 30, 2016
Filing Date:
June 03, 2011
Export Citation:
Assignee:
Bio-imaging Korea Shio., LDT.
International Classes:
C07D487/04; A61K51/00; C07B59/00
Domestic Patent References:
| JP2007204383A | ||||
| JP2007515465A |
Foreign References:
| WO2011042550A1 | ||||
| WO2011042529A1 |
Other References:
Eur. J. Org. Chem.,2008年,Issue 17,pp. 2853-2873
Attorney, Agent or Firm:
Hiroe Associates Patent Office
Previous Patent: A tricyclic Pyrazole sulfonamide compound, its manufacture, and directions for use
Next Patent: JPS6035329
Next Patent: JPS6035329