Title:
光学活性２−ヒドロキシエステルの製造方法
Document Type and Number:
Japanese Patent JP5605716
Kind Code:
B2
Abstract:
Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a carboxylic acid anhydride, or a carboxylic acid anhydride and a carboxylic acid. In particular, in the case where the solvent contains a carboxylic acid anhydride, but does not contain a carboxylic acid, as the carboxylic acid anhydride, a carboxylic acid anhydride containing a tertiary or quaternary carbon atom in the a-position is used. On the other hand, in the case where the solvent contains a carboxylic acid anhydride and a carboxylic acid, as the carboxylic acid, a carboxylic acid containing a tertiary or quaternary carbon atom in the ±-position is used.
Inventors:
Isamu Shiina
Takeya Nakata
Takeya Nakata
Application Number:
JP2011503808A
Publication Date:
October 15, 2014
Filing Date:
March 08, 2010
Export Citation:
Assignee:
Educational foundation Science University of Tokyo
International Classes:
C07C67/08; C07C69/24; C07C69/612; C07C69/76; C07F7/18; C07B53/00; C07B57/00; C07B61/00
Domestic Patent References:
| JPH0411898A | 1992-01-16 | |||
| JPH0411898A | 1992-01-16 |
Foreign References:
| WO2009113428A1 | 2009-09-17 | |||
| WO2008140074A1 | 2008-11-20 | |||
| WO2009113428A1 | 2009-09-17 | |||
| WO2008140074A1 | 2008-11-20 |
Other References:
JPN6014025163; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ４９（１０）, 2008, ｐ．１６０１-１６０４
Attorney, Agent or Firm:
Right wood Masayuki