Title:
光学活性アミノ酸誘導体の製造方法
Document Type and Number:
Japanese Patent JP5576791
Kind Code:
B2
Abstract:
The present application relates to a method for producing an optically active ±-amino acid derivative, comprising steps of reacting an ±-haloester derivative represented by the general formula (1):
of which alcohol part of the ester group is an optically active alcohol derivative, with an amine compound; then deprotecting the obtained compound; further carrying out an ester exchange reaction. According to the present invention method, it is possible to easily produce an optically active ±-amino acid ester derivative which is useful as an intermediate for drugs with high selectivity.
Inventors:
Shohei Yamamoto
Fujii Akio
Masaru Mitsuta
Fujii Akio
Masaru Mitsuta
Application Number:
JP2010515872A
Publication Date:
August 20, 2014
Filing Date:
June 02, 2009
Export Citation:
Assignee:
KANEKA Co.
International Classes:
C07C227/18; C07C229/08; C07C229/28; C07D211/60; C07D295/18; C07D495/04; C07B51/00; C07B53/00
Domestic Patent References:
| JP2006169158A | 2006-06-29 | |||
| JP2000501737A | 2000-02-15 | |||
| JP2004521124A | 2004-07-15 | |||
| JPS4532249B1 |
Foreign References:
| US20070072858A1 | 2007-03-29 |
Other References:
JPN6013056288; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６０， Ｎｏ．２１, ｐ．６７７６-６７８４ （１９９５）．
JPN6013056289; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４６， Ｎｏ．２３, ｐ．４１１５-４１１７ （２００５）．
JPN6013056290; Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．７７， Ｎｏ．４, ｐ．１１２４-１１６５ （１９９４）．
JPN6013056298; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ， Ｐｅｒｋｉｎ Ｔｒａｎｓａｃｔｉｏｎｓ １ Ｎｏ．２２, ｐ．３７４７-３７５７ （１９９８）．
JPN6013056292; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６４， Ｎｏ．２１, ｐ．７７００-７７０６ （１９９９）．
JPN6013056294; Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．５８， Ｎｏ．２２, ｐ．１１９-１２３ （２００２）．
JPN6013056296; Ｆｉｅｓｅｒ ａｎｄ Ｆｉｅｓｅｒ'ｓ Ｒｅａｇｅｎｔｓ ｆｏｒ Ｏｒｇａｎｉｃ Ｓｙｎｔｈｅｓｉｓ Ｃｏｌｌｅｃｔｉｖｅ Ｉｎｄｅｘ ｆｏｒ Ｖｏｌｕｍｅｓ １-１２, ｐ．１４１ （１９９０）．
JPN6013056289; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｖｏｌ．４６， Ｎｏ．２３, ｐ．４１１５-４１１７ （２００５）．
JPN6013056290; Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ Ｖｏｌ．７７， Ｎｏ．４, ｐ．１１２４-１１６５ （１９９４）．
JPN6013056298; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ， Ｐｅｒｋｉｎ Ｔｒａｎｓａｃｔｉｏｎｓ １ Ｎｏ．２２, ｐ．３７４７-３７５７ （１９９８）．
JPN6013056292; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．６４， Ｎｏ．２１, ｐ．７７００-７７０６ （１９９９）．
JPN6013056294; Ｈｅｔｅｒｏｃｙｃｌｅｓ Ｖｏｌ．５８， Ｎｏ．２２, ｐ．１１９-１２３ （２００２）．
JPN6013056296; Ｆｉｅｓｅｒ ａｎｄ Ｆｉｅｓｅｒ'ｓ Ｒｅａｇｅｎｔｓ ｆｏｒ Ｏｒｇａｎｉｃ Ｓｙｎｔｈｅｓｉｓ Ｃｏｌｌｅｃｔｉｖｅ Ｉｎｄｅｘ ｆｏｒ Ｖｏｌｕｍｅｓ １-１２, ｐ．１４１ （１９９０）．
Attorney, Agent or Firm:
Hisakazu Ueki
Hisahiko Ueki
Tadashi Sugawa
Hiroaki Ito
Hisahiko Ueki
Tadashi Sugawa
Hiroaki Ito