Title:
【発明の名称】高純度デフェロキサミン塩の製造法
Document Type and Number:
Japanese Patent JP3382297
Kind Code:
B2
Abstract:
A process for the preparation of high-purity deferoxamine salts from filtered fermentation liquors containing deferoxamine B as active ingredient by the adsorption of the active ingredient onto an ion exchange resin and the subsequent dissolution and purification thereof, which comprises carrying out the separation of the deferoxamine salt subsequent to the concentration of the eluate by salting out from an aqueous solution or from a mixture of water and an organic solvent and purifying it by repeated salting out and/or by methods known per se, and optionally a) preparing the methanesulfonate salt by known methods, or b) passing the aqueous solution of the deferoxamine salt trough an ion exchange resin containing methanesulfonate anions as counter ions and recovering the methanesulfonate salt from the effluent, preferably by lyophilization.
Inventors:
Zortan Cognari
Gyorgy Tote
Wilmos Keri
Janos Burlint
Antal Kovace
Judith Silage
Shandol Holkai
Ferenc Vinzi
Larslow Eseny
Chaba Sabo
Janos Erderyui
Nerli Chasse
Ilona Himeji
Gyorgy Tote
Wilmos Keri
Janos Burlint
Antal Kovace
Judith Silage
Shandol Holkai
Ferenc Vinzi
Larslow Eseny
Chaba Sabo
Janos Erderyui
Nerli Chasse
Ilona Himeji
Application Number:
JP12889893A
Publication Date:
March 04, 2003
Filing Date:
May 31, 1993
Export Citation:
Assignee:
Biogal Georgey Seljar El Tee
International Classes:
C07C239/18; C07C259/06; C07B63/00; (IPC1-7): C07C259/06
Domestic Patent References:
| JP334964A |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)