Title:
The many forms and its use of CDDO ethyl ester
Document Type and Number:
Japanese Patent JP5972986
Kind Code:
B2
Abstract:
The present invention relates to polymorphic forms of the compound of Formula I (i.e., ethyl 2-cyano-3,12-dioxoIeana-1,9(11)-dien-28-oate (CDDO ethyl ester)) and methods of using them for treating a variety of disease states such as cancer and condisitons associated with inflammation.
Inventors:
Jean, Xiao Hong
Rui Son
Sun, Wendon
Riu, Cayyan
Han, Chun Lei
Rui Son
Sun, Wendon
Riu, Cayyan
Han, Chun Lei
Application Number:
JP2014537484A
Publication Date:
August 17, 2016
Filing Date:
December 06, 2012
Export Citation:
Assignee:
Applied Pharmaceutical Sciences, Inc.
One, jean
Jean, Xiao Hong
One, jean
Jean, Xiao Hong
International Classes:
C07J63/00; A61K31/59; A61P1/04; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P17/00; A61P19/02; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00
Other References:
HONDA,TADASHI,ET AL.,"A Novel Dicyanotriterpenoid, 2-Cyano-3,12-dioxooleana-1,9(1 1)-dien-28-onithle,Active at Picomolar Concentrations for Inhibition of Nitric Oxide Production",BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2002年,VOL.12,NO.7,PP.1027-1030
DINKOVA-KOSTOVA,ALBENA T.,ET AL.,"Extremely potent triterpenoid inducers of the phase 2 esponse: correlations of protection against oxidant and inflammatory stress",PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005年,VOL.102,NO.12,PP.4584-4589
HONDA,TADASHI,ET AL.,"Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages",JOURNAL OF MEDICINAL CHEMISTRY,2000年,VOL.43,NO.22,PP.4233-4246
DINKOVA-KOSTOVA,ALBENA T.,ET AL.,"Extremely potent triterpenoid inducers of the phase 2 esponse: correlations of protection against oxidant and inflammatory stress",PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2005年,VOL.102,NO.12,PP.4584-4589
HONDA,TADASHI,ET AL.,"Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C: A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages",JOURNAL OF MEDICINAL CHEMISTRY,2000年,VOL.43,NO.22,PP.4233-4246
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation