Title:
ファルネシル誘導体およびそれらを含む医薬組成物
Document Type and Number:
Japanese Patent JP3757236
Kind Code:
B2
Abstract:
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents farnesyl, geranyl or geranyl-geranyl; Z represents C-R6 or N; R2 represents H, CN, the groups COOR7, SO3R7, CONR7R8 and SO2NR7R7, wherein R7 and R8 are each independently hydrogen, alkyl, alkenyl, and the groups COOM and SO3M, wherein M is a cation; R3, R4, R5 and R6 are each independently hydrogen, carboxyl, alkyl, alkenyl, aminoalkyl, nitroalkyl, nitro, halo, amino, mono- or di-alkylamino, mercapto, mercaptoalkyl, azido, or thiocyanato; X represents O, S, SO, SO2, NH or Se; and the quaternary ammonium salts and N-oxides of the compounds of formula I wherein Z is N.
Inventors:
Crog, Joel
Application Number:
JP51407895A
Publication Date:
March 22, 2006
Filing Date:
November 10, 1994
Export Citation:
Assignee:
Ramot University Authority For Applied Research and Industrial Development Limited
International Classes:
C07C323/62; C12N9/99; A61K31/19; A61K31/195; A61K31/44; A61P3/06; A61P35/02; A61P43/00; C07C43/215; C07C65/21; C07C69/92; C07C211/45; C07C211/49; C07C211/50; C07C211/52; C07C229/60; C07C235/44; C07C237/30; C07C247/16; C07C247/18; C07C331/08; C07C391/02; C07D213/79
Domestic Patent References:
| JP55036300B1 | ||||
| JP52020458B1 | ||||
| JP49024215B1 | ||||
| JP63227565A | ||||
| JP1153617A |
Foreign References:
| US3970758 | ||||
| DE2144954A | ||||
| US3957833 |
Other References:
DEVRIES,V.G. et al., Journal of Medicinal Chemistry, 1976年,Vol.19, No.7, p.946-957
LENG,X. et al., KUNCHONG ZHISHI, 1985年, Vol.22, No.4, p.164-166
FILHO,A.M.D. et al., Rev.Brasil.Biol., 1981年,Vol.41, No.1, p.197-203
PINCHIN,R. et al., Entomological Society of America, 1978年,Vol.71, No.6, p.950-955
PINCHIN,R. et al., Rev.Latinoamer.Quim., 1978年,Vol.9/4, p.195-196
KUZNETSOV,N.V. et al., Fiziologicheski Aktivnye Veshchestva, 1977年,Vol.9, p.27-29
SOLLI,H. et al., Pestic.Sci., 1976年,Vol.7, No.5, p.503-511
NILLES,G.P. et al., J.Agric.Food Chem., 1976年,Vol.24, No.4, p.699-708
LENG,X. et al., KUNCHONG ZHISHI, 1985年, Vol.22, No.4, p.164-166
FILHO,A.M.D. et al., Rev.Brasil.Biol., 1981年,Vol.41, No.1, p.197-203
PINCHIN,R. et al., Entomological Society of America, 1978年,Vol.71, No.6, p.950-955
PINCHIN,R. et al., Rev.Latinoamer.Quim., 1978年,Vol.9/4, p.195-196
KUZNETSOV,N.V. et al., Fiziologicheski Aktivnye Veshchestva, 1977年,Vol.9, p.27-29
SOLLI,H. et al., Pestic.Sci., 1976年,Vol.7, No.5, p.503-511
NILLES,G.P. et al., J.Agric.Food Chem., 1976年,Vol.24, No.4, p.699-708
Attorney, Agent or Firm:
Heikichi Odashima