Title:
【発明の名称】新規化合物、その製法及びそれを含む医薬組成物
Document Type and Number:
Japanese Patent JPH0832652
Kind Code:
B2
Abstract:
Compounds of formula (I) and pharmaceutically acceptable salts thereof:wherein:either one of R1 and R2 is hydrogen and the other is selected from the class of C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyloxy, C1-6 alkylhydroxymethyl, nitro, cyano, chloro, trifluoromethyl, C1-6 alkylsulphinyl, C1-6 alkylsulphonyl, C1-6 alkoxysulphinyl, C1-6 alkoxysulphonyl, C1-6 alkylcarbonylamino, C1-6 alkoxycarbonylamino, C1-6 alkyl-thiocarbonyl, C1-6 alkoxy-thiocarbonyl, C1-6 alkyl-thiocarbonyloxy, 1-mercapto C2-7 alkyl, formyl or aminosulphinyl, aminosulphonyl or aminocarbonyl, the amino moiety being optionally substituted by one or two C1-6 alkyl groups, or C1-6 alkylsulphinylamino, C1-6 alkylsulphonylamino, C1-6 alkoxysulphinylamino or C1-6 alkoxysulphonylamino or ethenyl terminally substituted by C1-6 alkylcarbonyl, nitro or cyano, or -(C1-6 alkyl-(NOH) or -C(C1-6 alkyl)NNH2 or, when Y is oxygen, one of R1 and R2 is nitro, cyano or C1-3 alkylcarbonyl and the other is methoxy or amino optionally substituted by C2-7 alkanoyl;one of R3 and R4 is hydrogen or C1-4 alkyl and the other is C1-4 alkyl or R2 and R3 together are C2-5 polymethylene;R5 is hydroxy, C1-6 alkoxy or C1-7 acyloxy;R6 is hydrogen or C1-6 alkyl;R7 is NR8R9 wherein R8 and R9 are independently C1-8 alkyl, R8 is hydrogen and R9 is C1-6 alkyl or R8 and R9 together are C4-5 polymethylene; or R6 and RB together are -(CH2)2- wherein n is 2 or 3, and R9 is hydrogen or C1-6 alkyl; or R7 is CH2R10 wherein R10 is hydrogen or C1-5 alkyl optionally substituted by halo, hydroxy or C1-6 alkoxy; or R6 and Rio are -(CH2)m- wherein m is 2 or 3;X is oxygen or sulphur; andY is oxygen, CH2 or NH;the R6-CH-CX-R7 group being trans to the R5 group; having blood pressure lowering activity, a process for their preparation and their use as pharmaceuticals.
Inventors:
FUREDERITSUKU KYASHIDEI
JEFURII SUTENPU
JEFURII SUTENPU
Application Number:
JP21183386A
Publication Date:
March 29, 1996
Filing Date:
September 10, 1986
Export Citation:
Assignee:
SMITHKLINE BEECHAM PLC
International Classes:
C07C49/245; A61K31/165; A61K31/215; A61K31/22; A61K31/265; A61K31/275; A61K31/35; A61K31/352; A61K31/443; A61K31/445; A61K31/47; A61P1/00; A61P9/00; A61P9/12; A61P11/00; A61P25/02; C07C45/00; C07C49/252; C07C49/255; C07C49/83; C07C49/84; C07C67/00; C07C201/00; C07C239/00; C07C301/00; C07C303/26; C07C303/30; C07C303/36; C07C303/40; C07C309/28; C07C313/00; C07C313/04; C07C313/06; C07C317/24; C07C317/46; C07C323/25; C07D215/20; C07D215/48; C07D311/58; C07D405/04; (IPC1-7): C07C49/252; A61K31/165; A61K31/275; A61K31/35; A61K31/47; C07C49/255; C07C49/83; C07C49/84; C07C69/24; C07C205/56; C07C233/25; C07C235/40; C07C251/48; C07C251/86; C07C255/57; C07C271/30; C07C309/74; C07C311/15; C07C313/24; C07C317/24; C07C323/22; C07C325/02; C07C327/44; C07D215/12; C07D311/58
Attorney, Agent or Firm:
Masamitsu Akizawa (1 person outside)
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