The method and constituent for restoration of the cartilage which uses an in vivo bioreactor

Japanese Patent JP6151006

B2

Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised ofHDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

Lionel Sea. Sebrain
Silvie W. Bardia-Sebrain

JP2012241637A

June 21, 2017

November 01, 2012

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Spinal Site, LRC

A61L27/38; A61K35/32; A61K35/33; A61L31/12; C12M1/00; C12M3/00; C12N5/077

US20010005592

Annals of Biomedical Engineering,Vol.32,No.1,2004,pp.50-56
Biomechanics Model Mechanobiol,Vol.3,No.3,2005,pp.141-146
Journal of Orthopaedic Research,Vol.21,No.3,2003,pp.451-457
川西誠他,脱分化ウシ関節軟骨細胞に対する静水圧負荷下3次元培養の効果,日本整形外科学会雑誌,Vol.79,No.8,2005,P.S782

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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