Title:
The method and constituent which use PDE4 inhibitor for the medical treatment and management of an autoimmune disease and an inflammatory disease
Document Type and Number:
Japanese Patent JP6022548
Kind Code:
B2
Abstract:
Methods of treating, preventing, or managing autoimmune inflammatory diseases and disorders including but not limited to spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis by the administration of phosphodiesterase 4 (PDE4) inhibitors in combination with other therapeutics are disclosed. Pharmaceutical compositions, dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Inventors:
Peter Schafuel
Anita Gandhi
Lori Capone
Anita Gandhi
Lori Capone
Application Number:
JP2014508578A
Publication Date:
November 09, 2016
Filing Date:
April 27, 2012
Export Citation:
Assignee:
Celgene Corporation
International Classes:
A61K38/00; A61K31/4035; A61P19/02; A61P29/00
Domestic Patent References:
| JP2005525386A | ||||
| JP2004510694A |
Other References:
近藤啓文、他1名,関節リウマチの薬物療法,臨牀と研究,2004年 2月,81巻2号,p18-22
橋本博史,膠原病に用いられる免疫抑制薬,Pharma Medica,2001年,Vo.19, No.7,p45-51
田中良哉、他1名,膠原病治療に於ける薬剤抵抗性の臨床と基礎,Jpn. J. Clin. Immunol.,2006年,Vol.29, No.5,p319-324
Roth-Eichhorn S, et al.,Anti-proliferative properties of the phosphodiesterase-4 inhibitor rolipram can supplement immunosuppressive effects of cyclosporine for treatment of obliterative bronchiolitis in heterotopic rat allografts,J Heart Lung Transplant.,2001年11月,Vol.20, No.11,p1188-1198
Massaia M, et al.,Cyclosporin A and dipyridamole: an effective combination against the generation of cytotoxic T lymphocytes (CTL),Pharmacol Res.,1992年,Vol.26, Supplement 2,p12, 13
橋本博史,膠原病に用いられる免疫抑制薬,Pharma Medica,2001年,Vo.19, No.7,p45-51
田中良哉、他1名,膠原病治療に於ける薬剤抵抗性の臨床と基礎,Jpn. J. Clin. Immunol.,2006年,Vol.29, No.5,p319-324
Roth-Eichhorn S, et al.,Anti-proliferative properties of the phosphodiesterase-4 inhibitor rolipram can supplement immunosuppressive effects of cyclosporine for treatment of obliterative bronchiolitis in heterotopic rat allografts,J Heart Lung Transplant.,2001年11月,Vol.20, No.11,p1188-1198
Massaia M, et al.,Cyclosporin A and dipyridamole: an effective combination against the generation of cytotoxic T lymphocytes (CTL),Pharmacol Res.,1992年,Vol.26, Supplement 2,p12, 13
Attorney, Agent or Firm:
Toru Ishikawa