A method for diagnosis of breast cancer transition, prognosis, and disposal

Japanese Patent JP6159254

B2

The present invention relates to a method for the diagnosis or the prognosis of metastasis in breast cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in ER- breast cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the ER- breast cancer metastasis.

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Gomis Cabre, Rogel
Tarragona Sniel, Maria
Arnal Estapé, Ana
Pavlovic, Milika

JP2013532235A

July 12, 2017

October 05, 2011

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Fundacio Instituto de Reserca Biomedica (Yerebe Barcelona)
Institucio Catalana de Reserca y Estudis Avansatz

C12Q1/68; A61K31/675; A61K31/7125; A61K31/713; A61K38/23; A61K39/395; A61K45/00; A61K48/00; A61P19/08; A61P35/04; C12N15/09; C12N15/113; G01N33/574; G01N37/00

JP2010518878A

Seminars in Oncology,2010年,Vol.37, No.3, Suppl 1,p.S12-S19
European Journal of Cancer,2010年,Vol.46,p.1211-1222
Therapeutic Advances in Medical Oncology,2009年,Vol.1, No.3,p.123-136

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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