Title:
光学活性（Ｓ）−（−）−２−（Ｎ−プロピルアミノ）−５−メトキシテトラリン及び（Ｓ）−（−）−２−（Ｎ−プロピルアミノ）−５−ヒドロキシテトラリン化合物の調製の方法
Document Type and Number:
Japanese Patent JP5595404
Kind Code:
B2
Abstract:
The present invention describes a novel process for the preparation of optically active (S)-(-)-2-(N-propylamino)-5-methoxytetraline and (S)-(-)-2-(N-propylamino)-5-hydroxytetraline compounds based on the optical resolution of mixtures of the enantiomers of 2-(N-propylamino)-5-methoxytetraline and 2-(N-propylamino)-5-hydroxytetraline respectively. This process comprises (a) reacting a mixture of the enantiomers of said compounds with an optically active organic acid to form diastereoisomeric salts and separating the salts by crystallization. Said compounds are useful in the preparation of (6S)-(-)-5,6,7,8-tetrahydro-6-[propyl-(2-thienyl)ethyl]amino-1-naphthol (Rotigotine). Rotigotine is a dopamine agonist and is indicated for the treatment of Parkinson's disease.
More Like This:
| JPS62185058 | RESOLUTION OF 1-AMINOINDANE |
Inventors:
マルキリャス オロンドリス, Francisco
ポマレス Marco, Marta
ポマレス Marco, Marta
Application Number:
JP2011530500A
Publication Date:
September 24, 2014
Filing Date:
October 09, 2009
Export Citation:
Assignee:
Intel Kim, ソシエダッド アノニマ
International Classes:
C07C213/10; C07C215/44; C07C217/52; C07C233/87; C07B57/00
Attorney, Agent or Firm:
Patent business corporation Asamura patent firm
Hiroshi Asamura
Hajime Asamura
Yoshiaki Watanabe
Teruo Naganuma
Yukihiro Ikeda
Seiko Kajiwara
Morio Niimura
Hisashi Kanamori
Yuko Nagase
Yoichi Inoue
Mari Yuge
Katsuhiko Shimomura
Hiroshi Asamura
Hajime Asamura
Yoshiaki Watanabe
Teruo Naganuma
Yukihiro Ikeda
Seiko Kajiwara
Morio Niimura
Hisashi Kanamori
Yuko Nagase
Yoichi Inoue
Mari Yuge
Katsuhiko Shimomura