Title:
選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用
Document Type and Number:
Japanese Patent JP5154954
Kind Code:
B2
Abstract:
The invention comprises compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions containing the compounds or prodrugs of the compounds. The invention also comprises animal models and methods of making the animal models for studying diseases and disorders related to deficiency or overexpression of O-GIcNAcase, accumulation or deficiency of O-GIcNAc, and treatment of such diseases and disorders. The invention also comprises methods of treating such diseases and disorders. The invention also comprises methods of making the compounds, and methods of making selective glycosidase inhibitors.
More Like This:
Inventors:
David Vocaloid
Whitworth, Garrett
Macquarie, Matthew
Stubs, keith
Whitworth, Garrett
Macquarie, Matthew
Stubs, keith
Application Number:
JP2007557300A
Publication Date:
February 27, 2013
Filing Date:
March 01, 2006
Export Citation:
Assignee:
Simon Fraser University
International Classes:
C07D309/30; A61K31/351; A61K31/7042; A61P3/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C07H9/00; C07H13/06
Foreign References:
| WO2004103368A1 |
Other References:
Helvetica Chimica Acta,2000年,Vol.83, No.1,p.114-118
Diabetes,2004年,Vol.53, No.4,921-930
Proceedings of the National Academy of Sciences of the United States of America,2002年,Vol.99, No.8,5313-5318
Diabetes,2004年,Vol.53, No.4,921-930
Proceedings of the National Academy of Sciences of the United States of America,2002年,Vol.99, No.8,5313-5318
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita