特定の粒径、形状、形態および組成を有するポリマー粒子の製造方法

Japanese Patent JP2007533798

A

The present invention provides a method and apparatus for producing polymeric particles with pre-designed size, shape, morphology and composition, and more particularly the present invention uses a microfluidic polymerization reactor for producing same. The present invention disclosed herein provides a process for producing polymer particles with pre-selected shapes. The method includes injecting a first fluid comprising a polymerizable constituent with a controlled flow rate into a microfluidic channel and injecting a second fluid with a controlled flow rate into the microfluidic channel in which the second fluid mixes with the first fluid, the second fluid being immiscible with the first fluid so that the first fluid forms into droplets in the microfluidic channel. The microfluidic channel has pre-selected dimensions to give droplets of pre-selected size, morphology and shape. The microfluidic channel is sufficiently long so that the droplets have a sufficiently long residence time in the channel so that they polymerize or otherwise harden into droplets of pre-selected size and shape.

Kumacheva, Eugenia
Shu, Schenkin
Knee, Tie Hong
Theo, Min, Theok
Louis, patrick, cameron
Tsang, Hong

JP2007508702A

November 22, 2007

April 25, 2005

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Kumacheva, Eugenia
Shu, Schenkin
Knee, Tie Hong
Theo, Min, Theok
Louis, patrick, cameron
Tsang, Hong

C08F2/00; A61K9/16; B29B13/08; C08F2/01; C08F2/16; C08F2/44; C08F2/46; C08F220/10; C08F283/12; C08G18/16; C08G18/32; C08G18/72; C08G85/00; C08J3/12; C08J3/28; C08J5/00; C08L75/04; A61K9/50

Yusuke Hiraki
Ishii Teiji
Satoshi Fujita

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