Title:
A method for producing and refining heterodimer protein and it
Document Type and Number:
Japanese Patent JP6022444
Kind Code:
B2
Abstract:
The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other heterodimeric proteins comprising immunoglubulin-like hinge sequences. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided.
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Inventors:
Wei Shen Ho
Jom pons
Arvind Rajpal
Pavel strap
Jom pons
Arvind Rajpal
Pavel strap
Application Number:
JP2013511236A
Publication Date:
November 09, 2016
Filing Date:
May 13, 2011
Export Citation:
Assignee:
Reinat Neuroscience Corporation
International Classes:
C12N15/02; A61K39/395; A61P35/00; C07K16/18; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Domestic Patent References:
| JP11500915A |
Foreign References:
| WO2009089004A1 | ||||
| WO2009006520A1 |
Other References:
K GUNASEKARAN,JOURNAL OF BIOLOGICAL CHEMISTRY,2010年 4月16日,V285 N25,P19637-19646
Attorney, Agent or Firm:
Noh four