A method for promoting graft survival of a hematopoietic stem cell

Japanese Patent JP6110309

B2

The present invention provides a novel method for enhancing engraftment of haematopoetic stem cells by an ex-vivo pretreatment comprising the steps of obtaining a sample containing haematopoetic stem cells and admixing a prostacyclin analog to obtain a mixture, incubating said mixture for a period of time sufficient to stimulate G alphas-signalling in said cells and optionally and isolating said stimulated cells. Further, a composition comprising a prostacyclin analog for use in the treatment of individuals undergoing haematopoetic stem cell transplantation is provided.

JP2006501169	Methods and compositions for targeting cells to tissues and organs using cellular asialodeterminants and complex sugars
WO/2014/075589	MESENCHYMAL STEM CELL INJECTION, PREPARATION METHOD THEREOF, AND APPLICATION THEREOF IN PREPARING DIABETES DRUG
WO/2013/003899	METHODS OF TREATING OR PREVENTING RHEUMATIC DISEASE

Freissmut, Michael
Tsevedin-Brandel, Efa-Maria
Bergmile, Christian
Hussein, Filza

JP2013548848A

April 05, 2017

January 13, 2012

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SciPharm S.a r.l.

A61K35/28; A61K9/20; A61K9/48; A61K31/352; A61K31/5575; A61K31/5578; A61K31/5585; A61K35/44; A61K35/50; A61P7/00; A61P35/02

JP2009530408A

WO2010054271A1
WO2010108028A1
WO2010036798A1
WO2010010909A1

OTSUKA HIROYUKI,THE PROSTACYCLIN ANALOG BERAPROST SODIUM AUGMENTS THE EFFICACY 以下備考,ANNALS OF VASCULAR SURGERY,米国,QUALITY MEDICAL PUBLISHING,2006年 9月 1日,V20 N5,P646-652,OF THERAPEUTIC ANGIOGENESIS INDUCED BY AUTOLOGOUS BONE MARROW CELLS
Blood. 2009 May 28;113(22):5444-55
Angiogenesis. 2011 Mar;14(1):17-27

Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takeda Takeshi

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