置換されたテトラサイクリン化合物を用いて、遺伝子または遺伝子産物の発現を調節する方法

Japanese Patent JP2009543544

A

The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to the compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of these tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.

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Nelson, Mark Elle.
Draper, Michael

JP2009511045A

December 10, 2009

May 15, 2007

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Paratech Pharmaceuticals, Inc.

C12N15/09; A61K31/166; A61K31/167; A61K31/17; A61K31/185; A61K31/196; A61K31/275; A61K31/341; A61K31/36; A61K31/382; A61K31/40; A61K31/4025; A61K31/415; A61K31/4155; A61K31/42; A61K31/426; A61K31/435; A61K31/438; A61K31/4409; A61K31/4418; A61K31/4425; A61K31/4439; A61K31/445; A61K31/4465; A61K31/451; A61K31/4525; A61K31/4545; A61K31/496; A61K31/4965; A61K31/505; A61K31/536; A61K31/5375; A61K31/5377; A61K35/74; A61K48/00; C07C237/26; C07C237/30; C07C255/24; C07C271/22; C07C275/30; C07C275/42; C07C309/61; C07C317/48; C07C323/58; C07D207/09; C07D207/12; C07D207/27; C07D207/34; C07D211/36; C07D211/58; C07D211/62; C07D213/56; C07D213/60; C07D213/74; C07D213/89; C07D231/12; C07D239/26; C07D261/08; C07D261/10; C07D261/18; C07D263/02; C07D265/12; C07D277/04; C07D277/18; C07D277/20; C07D277/42; C07D295/04; C07D295/16; C07D295/20; C07D307/16; C07D317/60; C07D335/02; C07D401/04; C07D401/12; C07D491/113; A61P5/00; A61P17/02; A61P19/02; A61P29/00; A61P35/00; A61P43/00

JPH11506901A	1999-06-22
JP2005506291A	2005-03-03
JP2004505012A	2004-02-19

WO2006047671A2	2006-05-04
WO2006047756A2	2006-05-04

JPN6012054057; Ｇｅｎｅ　Ｔｈｅｒａｐｙ ｖｏｌ．４, 1997, ｐｐ．９９３-９９７
JPN6012054058; Ａｎａｌｙｔｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ ｖｏｌ．３０９, 2002, ｐｐ．７９-８４
JPN6012054059; Ｖｉｒｕｓ　Ｒｅｓｅａｒｃｈ ｖｏｌ．１１５, 2006, ｐｐ．１６-２３

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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