Title:
ククルビツリルを結合されたシリカゲルを用いた静止相およびカラム、そして該カラムを用いたタキソールの分離方法
Document Type and Number:
Japanese Patent JP4651717
Kind Code:
B2
Abstract:
Provided are a stationary phase and a column using a cucurbituril-bound silica gel, and a method of separating taxane using the column. The taxane separation method includes: preparing a column for taxane separation, the column being packed with a stationary phase including a cucurbituril-bound silica gel in which a cucurbituril represented by Formula 1 or 2 is covalently bound to a modified silica gel represented by Formula 3; dissolving a taxane powder in a solvent to prepare a taxane-containing solution; applying the taxane-containing solution to the column; supplying a mobile-phase solvent to the column to obtain a taxane extract from the column; and purifying taxane from the taxane extract. Therefore, highly purified taxane can be separated from a low-purity crude taxane extract.
Inventors:
Kim ki moon
Koyoung-ho
Park Kyung-Min
Selva Paramun Narayanan
Nagarayan El Muipati Earl.
Koyoung-ho
Park Kyung-Min
Selva Paramun Narayanan
Nagarayan El Muipati Earl.
Application Number:
JP2008541062A
Publication Date:
March 16, 2011
Filing Date:
March 24, 2006
Export Citation:
Assignee:
POSTECH FOUNDATION
Postec Academy-Industry Foundation
Postec Academy-Industry Foundation
International Classes:
G01N30/88; B01D15/08; B01J20/281; C07D305/14
Domestic Patent References:
| JP2006521263A | ||||
| JP2005526708A | ||||
| JP2001122877A | ||||
| JP2004521949A | ||||
| JP2006520789A |
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue
Masato Ozeki