Title:
A method for treating a TWEAK related state
Document Type and Number:
Japanese Patent JP5916776
Kind Code:
B2
Abstract:
The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
Inventors:
Linda Berkeley
Aniela jackbowski
Timothy Zen
Kyun Min Harm
Aniela jackbowski
Timothy Zen
Kyun Min Harm
Application Number:
JP2014016608A
Publication Date:
May 11, 2016
Filing Date:
January 31, 2014
Export Citation:
Assignee:
Biogen MA Inc.
International Classes:
A01K67/027; A61K9/06; A61K38/00; A61K9/08; A61K9/10; A61K9/127; A61K9/16; A61K9/20; A61K9/48; A61K39/395; A61K45/00; A61P1/00; A61P1/16; A61P1/18; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P19/04; A61P25/00; A61P43/00; C07K14/28; C07K14/525; C07K14/705; C07K16/24; C07K16/28; C07K19/00; C12N5/074; C12N15/09; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53
Foreign References:
| WO2001045730A1 | ||||
| WO2000042073A1 | ||||
| WO2002022166A1 |
Other References:
Am. J. Pathol.,米国,2000年 4月,Vol.156, No.4,1253-1261
Hu, S. et al., Genomics, 1999, vol.62, no.1, p.103-7
Meighan-Mantha, R.L. et al., J. Biol. Chem., 1999, vol.274, no.46, p.33166-76
Chicheportiche, Y. et al., Biochem. Biophys. Res. Commun., 2000, vol.279, no.1, p.162-5
Hu, S. et al., Genomics, 1999, vol.62, no.1, p.103-7
Meighan-Mantha, R.L. et al., J. Biol. Chem., 1999, vol.274, no.46, p.33166-76
Chicheportiche, Y. et al., Biochem. Biophys. Res. Commun., 2000, vol.279, no.1, p.162-5
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita