The molecule for treating an inflammatory obstacle

Japanese Patent JP6141018

B2

The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-1RAcP in order to increase the amount of a soluble IL-1RAcP. The invention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.

Juan Omen, Garrit-Jan Bowdewien
Aalto Sumarus, Anne Mique
Juan Deutcom, Judith Christina Theodora
De Kinpe, Josephus Johannes
Felbeek, Joseph Stefan
Eelmaz-Ellis, Arye Seda

JP2012545883A

June 07, 2017

December 22, 2010

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Biomarine Technologies B.F.

C12N15/113; A61K31/7088; A61K45/00; A61K48/00; A61P1/04; A61P1/16; A61P3/06; A61P17/06; A61P19/00; A61P19/02; A61P29/00; A61P43/00

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Arthritis & Rheumatism,2003,Vol.48,No.10,p.2949-2958

Kurata Masatoshi
Nobuhisa Nogawa
Naoki Kono
Tadashi Inoue
Ukai Ken

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