A monoclonal antibody specific to the main neutralization epitopes of influenza H5 hemagglutinin

Title:

A monoclonal antibody specific to the main neutralization epitopes of influenza H5 hemagglutinin

Document Type and Number:

Japanese Patent JP6101204

Kind Code:

B2

Abstract:

The present invention relates to the murine monoclonal antibody 4C2 or to chimeric or humanized monoclonal antibodies specific to a major neutralizing epitope of influenza H5 hemagglutinin and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of H5N1 influenza using such murine or chimeric or humanized monoclonal antibodies or fragments thereof.

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Inventors:

Mukhan, Prava Kallan
F, Fang
Kwan, Faye-Shin Jimmy

Application Number:

JP2013525868A

Publication Date:

March 22, 2017

Filing Date:

August 23, 2010

Export Citation:

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Assignee:

Temasek Life Sciences Laboratory Limited

International Classes:

C12N15/09; A61K39/395; A61K48/00; A61P31/16; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08

Domestic Patent References:

JP2013525428A
JP2011514321A
JP2010539162A
JP2010539161A
JP2010526880A

Other References:

PLoS ONE(2009.May)Vol.4,No.5,p.e5672

Attorney, Agent or Firm:

Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu

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