Title:
A new benzoazepine derivative and its medicine use
Document Type and Number:
Japanese Patent JP6231621
Kind Code:
B2
Abstract:
An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below:
[wherein R 1 is the formula described below:
(wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof.
Inventors:
Katsunori Kitamoto
Nobuyoshi Kasugai
Hiroyo Kataoka
Yasushi Osawa
Yuka Kuno
Hiroki Fujieda
Keita Sakai
Hiroki Nagano
Naoki Takahashi
Toru Ido
Mitsuaki Takeuchi
Daisuke Kurazuka
Toshiyuki Miyazawa
Satoko Harada
Izumi Goto
Yukiya Asano
Yuri Yamada
Okabe Morio
Nobuyoshi Kasugai
Hiroyo Kataoka
Yasushi Osawa
Yuka Kuno
Hiroki Fujieda
Keita Sakai
Hiroki Nagano
Naoki Takahashi
Toru Ido
Mitsuaki Takeuchi
Daisuke Kurazuka
Toshiyuki Miyazawa
Satoko Harada
Izumi Goto
Yukiya Asano
Yuri Yamada
Okabe Morio
Application Number:
JP2016133380A
Publication Date:
November 15, 2017
Filing Date:
July 05, 2016
Export Citation:
Assignee:
Sanwa Chemical Laboratory Co., Ltd.
International Classes:
C07D223/16
Domestic Patent References:
| JP5968466B1 | ||||
| JP2010504352A |