ニコチン性アセチルコリン受容体リガンドとして有用な新規1,4-ジアザ-ビシクロ〔3.2.2〕ノニルヘテロアリール誘導体

Japanese Patent JP2010536726

A

This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Peters, Dan
Dimmermann, Daniel, Bee.
Nielsen, Elsevet, Esterguard
Olsen, Gunnar, M.
Dealing, Tino
Christensen, Jeppe, Caser

JP2010520576A

December 02, 2010

August 14, 2008

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Neurosearch Actizel Scab

C07D471/08; A61K31/551; A61P1/04; A61P1/12; A61P3/04; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P15/06; A61P15/08; A61P15/10; A61P17/00; A61P17/10; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P29/00

Asamura patent office
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Kajiwara Saiko
Shinmura Morio
Kanamori Koji
Yuko Nagase
Youichi Inoue
Mari Yuge
Yoshitaka Watanabe

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