Title:
β-セクレターゼ(BACE)のインヒビターとして有用な新規の2-アミノ-キナゾリン誘導体
Document Type and Number:
Japanese Patent JP5046932
Kind Code:
B2
Abstract:
The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ß-secretase, also known as ß-site cleaving enzyme and BACE.
Inventors:
Ellen Baxter
Robert, Boyd
Coats, steve
Jiyodan, Alfonzo
Rights, allen
Reynolds, CH
Scott, Malcolm
Schirz, Mark
Robert, Boyd
Coats, steve
Jiyodan, Alfonzo
Rights, allen
Reynolds, CH
Scott, Malcolm
Schirz, Mark
Application Number:
JP2007525078A
Publication Date:
October 10, 2012
Filing Date:
August 08, 2005
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D239/84; A61K31/517; A61K31/7064; A61P25/00; A61P25/16; A61P25/28; A61P43/00; C07D401/04; C07D401/06; C07D401/12; C07D403/08; C07D403/12; C07D405/06; C07D405/08; C07D413/10; C07H15/04
Domestic Patent References:
| JP8151377A | ||||
| JP58046088A |
Foreign References:
| WO2004082616A1 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office