Title:
新規な、ＮＩＫ阻害剤としての３−（１Ｈ−ピラゾール−４−イル）−１Ｈ−ピロロ［２，３−ｃ］ピリジン誘導体
Document Type and Number:
Japanese Patent JP6404332
Kind Code:
B2
Abstract:
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Inventors:
Hind, George
Tisseli, Patrizia
Clark, David Edward
Kragowski, Janus Joseph
Macleod, Calum
Man, samuel edward
Roussel, Fabian Jean Gislan
Price, Stefan Colin
John Gary, Montana
Tisseli, Patrizia
Clark, David Edward
Kragowski, Janus Joseph
Macleod, Calum
Man, samuel edward
Roussel, Fabian Jean Gislan
Price, Stefan Colin
John Gary, Montana
Application Number:
JP2016516870A
Publication Date:
October 10, 2018
Filing Date:
September 25, 2014
Export Citation:
Assignee:
Janssen Pharmaceuticals N.B.
International Classes:
C07D471/04; A61K31/437; A61K31/4545; A61P35/00; A61P43/00
Domestic Patent References:
| JP2016517859A | ||||
| JP2011525915A | ||||
| JP11263789A | ||||
| JP2009516653A | ||||
| JP2003511373A |
Foreign References:
| WO2012123522A1 | ||||
| WO2010042337A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Junko Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki
Junko Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki