Title:
抗炎症性および免疫抑制性活性を有する新規ベンズアミジン誘導体
Document Type and Number:
Japanese Patent JP4104984
Kind Code:
B2
Abstract:
Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, R1 is selected from an alkyl group having from 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with the nitro group or the methyl group, R2 is selected independently from hydrogen, an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups, R3 and R4 are selected independently from hydrogen and an alkyl group having from 1 to 3 carbon atoms, R5 represents one or two substituents independently selected from hydrogen and the methyl, methoxyl and hydroxyl groups, n is a whole number from 0 to 6, and the amidine group is in the para or meta position relative to the "-A-NH-" group.
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Inventors:
Francesco Makovek
Simona Tanzala
Robert Altusi
Lucho claudio lovati
Simona Tanzala
Robert Altusi
Lucho claudio lovati
Application Number:
JP2002569789A
Publication Date:
June 18, 2008
Filing Date:
February 06, 2002
Export Citation:
Assignee:
ROTTAPHARM S.p.A.
International Classes:
C07C257/14; A61K31/167; C07D277/10; A61K31/17; A61K31/404; A61K31/426; A61K31/4402; A61P1/04; A61P19/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07C257/22; C07C279/18; C07C279/36; C07C335/20; C07D209/14; C07D209/40; C07D213/36; C07D213/40; C07D277/48
Domestic Patent References:
| JP2000515493A | ||||
| JP2000506538A | ||||
| JP62223177A | ||||
| JP50154223A | ||||
| JP53065848A |
Foreign References:
| FR2456731A1 | ||||
| GB1291994A |
Attorney, Agent or Firm:
Kyousei Tamura
Nagatoshi Shinagawa
Nagatoshi Shinagawa