Title:
選択的エストロゲン受容体モジュレーターとしての新規なヘテロ原子含有四環状誘導体
Document Type and Number:
Japanese Patent JP2006514941
Kind Code:
A
Abstract:
The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and/or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
Inventors:
Kanoshiya, Lameille M
The Ain, Naresyu Kumar Ev
Nugu, Raymond
Sui, Zihua
Sue, The Eye
The Ain, Naresyu Kumar Ev
Nugu, Raymond
Sui, Zihua
Sue, The Eye
Application Number:
JP2004557261A
Publication Date:
May 18, 2006
Filing Date:
November 21, 2003
Export Citation:
Assignee:
Ortho-McNeill Pharmacy Incorporated
International Classes:
C07D493/04; A61K31/35; A61K31/352; A61K31/366; A61K31/40; A61K31/453; A61K31/5377; A61K31/55; A61P3/06; A61P5/30; A61P9/00; A61P13/08; A61P15/00; A61P15/16; A61P15/18; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; C22B3/06; C22B3/10; C22B11/00; A61K31/695
Attorney, Agent or Firm:
Heikichi Odashima