Title:
後期糖化最終生成物(AGE)形成の新規阻害剤
Document Type and Number:
Japanese Patent JP5209832
Kind Code:
B2
Abstract:
Derivatives of aryl and heterocyclic ureido and aryl and heterocyclic carboxamido phenoxy isobutyric acids have been found to inhibit the nonenzymatic glycation of proteins which often results in formation of advanced glycation endproducts and crosslinks. Many other phenoxyisobutyric acid derivatives as well as certain other compounds as set out in this disclosure also have been found to inhibit the nonenzymatic glycation of proteins. The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood and in the intracellular environment such as occurs with diabetes. The structural and functional integrity of the affected molecules become perturbed by these modifications and can result in severe consequences. The compounds of the present invention can be used to inhibit this process of nonenzymatic glycation and therefore to inhibit some of the ill effects caused by diabetes or by aging. The compounds are also useful for preventing premature aging, spoilage of proteins in food and can prevent discoloration of teeth.
Inventors:
Laver, Samuel
Lalezzari, Iraj
Lalezzari, Iraj
Application Number:
JP2000609388A
Publication Date:
June 12, 2013
Filing Date:
April 05, 2000
Export Citation:
Assignee:
City of Hope
International Classes:
A61K31/517; A23L3/34; C07D295/20; A61K31/155; A61K31/167; A61K31/17; A61K31/192; A61K31/194; A61K31/195; A61K31/196; A61K31/198; A61K31/27; A61K31/341; A61K31/381; A61K31/402; A61K31/4035; A61K31/435; A61K31/44; A61K31/4406; A61K31/4409; A61K31/47; A61K31/472; A61K31/5375; A61P3/10; A61P9/10; A61P13/12; A61P19/02; A61P25/00; A61P25/28; A61P31/10; A61P43/00; A61Q11/00; C07C59/52; C07C59/68; C07C65/03; C07C65/21; C07C69/157; C07C217/84; C07C221/00; C07C229/60; C07C229/64; C07C233/29; C07C233/54; C07C233/73; C07C233/75; C07C233/87; C07C235/14; C07C235/24; C07C235/88; C07C237/36; C07C249/02; C07C275/30; C07C275/34; C07C275/38; C07C275/42; C07C279/26; C07C311/13; C07C311/16; C07C323/59; C07D209/48; C07D213/75; C07D215/26; C07D215/50; C07D239/96; C07D307/68; C07D333/38
Domestic Patent References:
| JP2503797A | ||||
| JP3505728A | ||||
| JP61009227A | ||||
| JP62022517A | ||||
| JP62032880A |
Other References:
Iraj Lalezari et al.,Journal of Medicinal Chemistry,1989年,Vol. 32,p. 2352-2357
Stanislaw Ostrowski et al.,Magnetic Resonance in Chemistry,1994年,Vol. 32, No. 3,p. 182-183
Stanislaw Ostrowski et al.,Magnetic Resonance in Chemistry,1994年,Vol. 32, No. 3,p. 182-183
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Hiroko Ejiri
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Hiroko Ejiri