Title:
改善された非沈静α2アゴニストを同定するための新規方法
Document Type and Number:
Japanese Patent JP2007505112
Kind Code:
A
Abstract:
The present invention provides methods of preventing or alleviating sympathetically-enhanced conditions, neurological conditions, ocular conditions and chronic pain without concomitant sedation by peripherally administering to a subject an effective amount of an alpha-2A/alpha-1A selective agonist, thereby preventing or alleviating the condition or chronic pain without concomitant sedation, where the selective agonist has an alpha-1A efficacy less than that of brimonidine or a ratio of alpha-1A/alpha-2A potency greater than that of brimonidine.
Inventors:
Daniel W. Gill
John E. Donello
John E. Donello
Application Number:
JP2006526109A
Publication Date:
March 08, 2007
Filing Date:
August 19, 2004
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
A61K45/00; A61K9/70; A61K31/137; A61K31/4164; A61K31/4168; A61K31/4174; A61K31/433; A61K31/498; A61P1/04; A61P1/14; A61P3/00; A61P3/04; A61P3/10; A61P5/50; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P15/08; A61P17/00; A61P17/06; A61P21/02; A61P25/00; A61P25/02; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/36; A61P27/02; A61P27/06; A61P29/00; A61P31/18; A61P31/22; A61P35/00; A61P41/00; A61P43/00
Foreign References:
| WO2001078702A2 | 2001-10-25 |
Attorney, Agent or Firm:
Kyousei Tamura
Yushiro Tsuboi
Nagatoshi Shinagawa
Yushiro Tsuboi
Nagatoshi Shinagawa
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