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Title:
光学的に純粋な2-モルフィノール誘導体を調製する新規な方法
Document Type and Number:
Japanese Patent JP2007510630
Kind Code:
A
Abstract:
The present invention relates to a process for preparing optically pure (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates from a mixture of (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and (-)-(2R,3R)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol. The process utilizes continuous chromatography, including techniques like Multi Column Chromatography (MCC), VARICOL, and Cyclojet.

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Inventors:
Philip Adam
Olivier Rudeman-Ombourget
Area nuzzi
David Simon Ross
Mireille Scheffe
Christina Stu
Application Number:
JP2006537165A
Publication Date:
April 26, 2007
Filing Date:
October 25, 2004
Export Citation:
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Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D265/32; C07B55/00; C07B57/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Tadayuki Motoyama
Kenji Tomita



 
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