Title:
新規ナフタレン化合物、その製造法、およびそれを含有する薬学的組成物
Document Type and Number:
Japanese Patent JP4675938
Kind Code:
B2
Abstract:
N-[3-Hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide (I), its enantiomers and base addition salts, are new. N-[3-Hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide of formula (I), its enantiomers and base addition salts, are new. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Cerebroprotective; Contraceptive; Endocrine-Gen; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The ability of (I) to bind with melatonin was tested. The results showed that N-[3-hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide exhibited an inhibition constant value of 1.4 nM and 3.2 nM to bind with melatonin receptors MT 1 and MT 2, respectively.
Inventors:
Side Yu
Basile Pale
Ahmed Sabauni
Pascal Bertolo
Michael spading
Philippe De Lagrange
Daniel-Henri Cagnar
Marc Milan
Basile Pale
Ahmed Sabauni
Pascal Bertolo
Michael spading
Philippe De Lagrange
Daniel-Henri Cagnar
Marc Milan
Application Number:
JP2007171622A
Publication Date:
April 27, 2011
Filing Date:
June 29, 2007
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
C07C233/18; A61K31/165; A61P3/04; A61P3/10; A61P9/00; A61P15/10; A61P15/18; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/26; A61P25/28; A61P35/00; A61P37/02; A61P43/00; C07B57/00; C07C231/02; C07C231/20; C07C231/24
Domestic Patent References:
| JP2008013556A | ||||
| JP11263761A | ||||
| JP6049011A |
Other References:
Journal of Medicinal Chemistry,Vol.41, No.23,p.4453-4465 (1998).
Bioorganic & Medicinal Chemistry,Vol.7, No.12,p.2945-2952 (1999).
Journal of Medicinal Chemistry,Vol.37, No.20,p.3231-3239 (1994).
Archiv der Pharmazie,Vol.326, No.2,p.119-120 (1993).
Journal of Medicinal Chemistry,Vol.25, No.6,p.723-730 (1982).
Bioorganic & Medicinal Chemistry,Vol.7, No.12,p.2945-2952 (1999).
Journal of Medicinal Chemistry,Vol.37, No.20,p.3231-3239 (1994).
Archiv der Pharmazie,Vol.326, No.2,p.119-120 (1993).
Journal of Medicinal Chemistry,Vol.25, No.6,p.723-730 (1982).
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito