Title:
抗糖尿病性および抗炎症性を有するコロソリン酸の新規構造類似体
Document Type and Number:
Japanese Patent JP4732454
Kind Code:
B2
Abstract:
This invention relates to novel corosolic acid analogs of the formula I, wherein R1, R2, R3, R4 and R5 are described herein. These compounds exhibit good hypoglycemic and 5-lipoxygenase inhibitory activities. They also inhibit tumour growth. Pharmaceutical compositions containing known adjutants and the title compounds are also within the scope of this invention.
More Like This:
| WO/2019/054379 | OLEANOLIC ACID DERIVATIVE |
| WO/2013/020246 | METHYLENE DERIVATIVES OF BETULIN |
Inventors:
Gocaraj, Ganga, Raju
Gocaraj, Rama, Raj
Gotsumkara, Venkata, Subaraj
Gorakochi, Trim Cree
Somei Paris, Venkateswaluru
Chilavuri, Venkateswara, Lao
Gocaraj, Rama, Raj
Gotsumkara, Venkata, Subaraj
Gorakochi, Trim Cree
Somei Paris, Venkateswaluru
Chilavuri, Venkateswara, Lao
Application Number:
JP2007519984A
Publication Date:
July 27, 2011
Filing Date:
July 08, 2004
Export Citation:
Assignee:
Lyra Nutraceuticals
International Classes:
C07J63/00; A61K31/11; A61K31/16; A61K31/164; A61K31/167; A61K31/185; A61K31/19; A61K31/215; A61K31/221; A61K31/223; A61K31/365; A61K31/39; A61K31/4406; A61K31/495; A61P3/10; A61P29/00; A61P35/00; A61P43/00; C07J71/00
Domestic Patent References:
| JP2002205949A |
Other References:
PRAKASH CHATURVEDULA, V. S.,A New Ursane Triterpene from Monochaetum vulcanicum that Inhibits DNA Polymerase β Lyase,Journal of Natural Products,2004年,67(5),p. 899-901
YAMAGISHI, T.,The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B,Phytochemistry,1988年,27(10),p. 3213-3216
OGURA, M.,Potential Anticancer Agents. IV. Constituents of Jacaranda caucana Pittier (Bignoniaceae),LLOYDIA,1977年,40(2),p. 157-168
GLEN, A. T.,Triterpenoid Constituents of Rose-bay Willow-herb,Journal of the Chemical Society (C),1967年,p. 510-515
IKUTA, A.,Ursane- and Oleanane-Type Triterpenes from Ternstroemia gymnanthera Callus Tissues,Journal of Natural Products,2003年,66(8),p. 1051-1054
TALAPATRA, B.,Lagerenyl acetate and lagerenol, two tetracyclic triterpenoids with the cycloartane skeleton from Lagerstroemia lancasteri,Phytochemistry,1983年,22(11),p. 2559-2562
HABERLEIN, H.,Triterpenoids and flavonoids from Leptospermum scoparium,Phytochemistry,1994年,35(3),p. 765-768
FANG, J.,Steroids and triterpenoids from Rosa laevigata,Phytochemistry,1991年,30(10),p. 3383-3387
YAMAGISHI, T.,The cytotoxic principles of Hyptis capitata and the structures of the new triterpenes hyptatic acid-A and -B,Phytochemistry,1988年,27(10),p. 3213-3216
OGURA, M.,Potential Anticancer Agents. IV. Constituents of Jacaranda caucana Pittier (Bignoniaceae),LLOYDIA,1977年,40(2),p. 157-168
GLEN, A. T.,Triterpenoid Constituents of Rose-bay Willow-herb,Journal of the Chemical Society (C),1967年,p. 510-515
IKUTA, A.,Ursane- and Oleanane-Type Triterpenes from Ternstroemia gymnanthera Callus Tissues,Journal of Natural Products,2003年,66(8),p. 1051-1054
TALAPATRA, B.,Lagerenyl acetate and lagerenol, two tetracyclic triterpenoids with the cycloartane skeleton from Lagerstroemia lancasteri,Phytochemistry,1983年,22(11),p. 2559-2562
HABERLEIN, H.,Triterpenoids and flavonoids from Leptospermum scoparium,Phytochemistry,1994年,35(3),p. 765-768
FANG, J.,Steroids and triterpenoids from Rosa laevigata,Phytochemistry,1991年,30(10),p. 3383-3387
Attorney, Agent or Firm:
Yuichi Yamada
Ikeda adult
Kazuhiro Yamaguchi
Masakazu Noda
Ikeda adult
Kazuhiro Yamaguchi
Masakazu Noda