Title:
Ｓ−ニトロソグルタチオンレダクターゼ阻害薬としての新規な置換二環芳香族化合物
Document Type and Number:
Japanese Patent JP5898230
Kind Code:
B2
Abstract:
The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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Inventors:
Sun, Sichen
Chiu, Jien
Stout, adam
Chiu, Jien
Stout, adam
Application Number:
JP2013544827A
Publication Date:
April 06, 2016
Filing Date:
December 16, 2011
Export Citation:
Assignee:
Nivalis Therapeutics Incorporated
International Classes:
C07C65/11; A61K31/192; A61K31/196; A61K31/277; A61K31/41; A61K31/4192; A61K31/4418; A61K31/455; A61K31/4965; A61K31/50; A61K31/505; A61K31/5375; A61P1/00; A61P11/00; A61P11/06; A61P43/00; C07C65/24; C07C229/60; C07C255/57; C07D213/79; C07D213/80; C07D237/24; C07D239/28; C07D241/24; C07D249/18; C07D257/04; C07D295/155
Domestic Patent References:
| JP2009508952A | ||||
| JP2010523484A |
Foreign References:
| WO2010019905A1 | ||||
| WO2010019903A1 | ||||
| WO2010019909A1 | ||||
| WO2010019910A1 |
Other References:
C.G.WERMUTH編,『最新 創薬化学 上巻』,株式会社テクノミック,1998年 8月15日,235-271頁,13章 等価置換に基づく分子の変換
野崎正勝ら,創薬化学,化学同人,1995年,p.98-99
Sanghani, Paresh C. et al,Kinetic and Cellular Characteization of Novel Inhibitors of S-Nitrosoglutathione Reductase,Journal of Biological Chemistry,2009年,Vol.284, No.36,pages 24354-24362
Bateman,Raynard L. et al,Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase,Journal of Biological Chemistry,2008年,Vol.283, No.51,pages 35756-35762
野崎正勝ら,創薬化学,化学同人,1995年,p.98-99
Sanghani, Paresh C. et al,Kinetic and Cellular Characteization of Novel Inhibitors of S-Nitrosoglutathione Reductase,Journal of Biological Chemistry,2009年,Vol.284, No.36,pages 24354-24362
Bateman,Raynard L. et al,Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase,Journal of Biological Chemistry,2008年,Vol.283, No.51,pages 35756-35762
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Mitsutoshi Nakamura
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Mitsutoshi Nakamura