Title:
o-置換ベンゾイルグアニジン、その製造方法およびそれを含有する医薬
Document Type and Number:
Japanese Patent JP3558224
Kind Code:
B2
Abstract:
Ortho-substituted benzoylguanidines of the formula I where: R(1) is equal to halogen, alkyl, -X-R(6), where X is equal to O, S, NR(7) or Y-ZO and R(6) is equal to H, (cyclo)(halo)alkyl(methyl), -CnH2n-phenyl, R(3) is equal to H, -X-R(6), R(2) and R(4) are equal to R(11)-SO1-2-, (di)-alkyl-N-SO2-, or one of the two radicals R(2) or R(4) is equal to hydrogen or is defined as R(1), R(5) is equal to H, methyl, F, Cl, methoxy, and their pharmaceutically acceptable salts. They are obtained by a process in which compounds of the formula II in which R(1) to R(5) have the meaning mentioned and L represents a leaving group which can be easily substituted nucleophilically, are reacted with guanidine. The compounds I are used for producing a medicament for the treatment and the prophylaxis of heart-rhythm disorders and ischaemically induced damage, as well as for producing a medicament for the inhibition of cell proliferation.
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Inventors:
Hans-Yohen Lang
Andreas Wueichert
Heinrich Engrat
Wolfgang Schjorz
Oud Arbus
Florian Lang
Andreas Wueichert
Heinrich Engrat
Wolfgang Schjorz
Oud Arbus
Florian Lang
Application Number:
JP2310893A
Publication Date:
August 25, 2004
Filing Date:
February 12, 1993
Export Citation:
Assignee:
Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/18; A61P1/16; A61P3/08; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P13/02; A61P15/00; A61P35/00; C07C311/21; C07C311/37; C07C311/39; A61K31/155; C07C311/47; C07C317/42; C07C317/44; C07C323/65; C07D295/155; C07D295/22; C07D295/26; (IPC1-7): C07C317/44; C07C311/37; C07C311/39; C07C323/65; C07D295/22
Domestic Patent References:
| JP3106858A |
Foreign References:
| US3780027 |
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Kosuke Nishimura