Title:
p38MAPキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP5340918
Kind Code:
B2
Abstract:
Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: wherein: G is —N═ or —CH═; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6 is hydrogen or optionally substituted C1-C3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2)z—X1-L1-Y—NH—CHR1R2 wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z, Y, L1, and X1 are as defined in the specification; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 is the side chain of a natural or non-natural alpha amino acid.
Inventors:
Moffat, David, Charles, Festus
Pintat, Stephan
Davis, Stephen
Pintat, Stephan
Davis, Stephen
Application Number:
JP2009508455A
Publication Date:
November 13, 2013
Filing Date:
May 01, 2007
Export Citation:
Assignee:
CHROMA THERAPEUTICS LTD
International Classes:
C07D213/73; A61K31/4418; A61K31/5377; A61P1/04; A61P3/10; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P29/00; A61P37/02; A61P37/06; A61P43/00
Domestic Patent References:
| JP2005526068A |
Foreign References:
| WO2006117567A1 |
Attorney, Agent or Firm:
Shintaro Nogawa