Title:
TOPICAL COMPOSITIONS COMPRISING FIPRONIL AND PERMETHRIN AND METHODS OF USE
Document Type and Number:
Japanese Patent JP2017210477
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide stable, highly-effective topical formulations comprising permethrin, fipronil, and a solvent system in which these two active ingredients are sufficiently dissolved and which limits degradation of fipronil to its sulfone.SOLUTION: Formulations of the present invention comprise approximately 30% to approximately 55% (w/w) permethrin, approximately 2-15% (w/w) fipronil, and a solvent system that comprises N-methylpyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, where the N-methylpyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight-to-weight ratio of the glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to the N-methylpyrrolidone from approximately 1:2.0 to approximately 1:3.5.SELECTED DRAWING: Figure 1
Inventors:
MARK DAVID SOLL
JAMES PATE
LISA A BAKER
JAMES PATE
LISA A BAKER
Application Number:
JP2017139772A
Publication Date:
November 30, 2017
Filing Date:
July 19, 2017
Export Citation:
Assignee:
MERIAL INC
International Classes:
A61K31/415; A01N25/02; A01N47/02; A01N53/08; A01P7/02; A01P7/04; A61K9/08; A61K31/222; A61K47/14; A61K47/22; A61K47/44; A61P33/14; A61P43/00
Domestic Patent References:
| JP6183861B2 | 2017-08-23 | |||
| JPH1149618A | 1999-02-23 | |||
| JP2011157355A | 2011-08-18 | |||
| JP2010155844A | 2010-07-15 | |||
| JP2002536423A | 2002-10-29 |
Attorney, Agent or Firm:
Shinichiro Tanaka
Disciple Maru Ken
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Gen Tashiro
Disciple Maru Ken
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Hironobu Hattori
Gen Tashiro