Title:
マクロライド系T細胞免疫調節剤および光老化防止剤を含む医薬組成物
Document Type and Number:
Japanese Patent JP2008517972
Kind Code:
A
Abstract:
Compositions are provided comprising a macrolide T-cell immunomodulator or immunosuppressant agent, e.g. pimecrolimus, and at least one anti-photoaging agent such as a sunscreen, an anti-oxidant or a DNA-repair enzyme. They are useful in particular in the curative treatment or prevention of dermatological diseases and of conditions where it is desired to inhibit the skin aging effects of light radiation such as UV-A and UV-B light, e.g. development of skin cancer.
Inventors:
Thomas HULTSCH
Carl Paul
Nabila Sekkato
Stephan Hirsch
Carl Paul
Nabila Sekkato
Stephan Hirsch
Application Number:
JP2007538367A
Publication Date:
May 29, 2008
Filing Date:
November 14, 2005
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
A61K45/06; A61K8/34; A61K8/49; A61K8/60; A61K8/67; A61K31/05; A61K31/085; A61K31/125; A61K31/355; A61K31/375; A61K31/436; A61K31/706; A61K33/24; A61P3/02; A61P17/16; A61P17/18; A61P37/02; A61P37/06; A61Q17/04; A61Q19/00; A61Q19/08
Other References:
JPN6010028982, ＵＥＴＳＵ，Ｎ． ｅｔ ａｌ, "Ｔｒｅａｔｍｅｎｔ ｏｆ ｃｈｒｏｎｉｃ ａｃｔｉｎｉｃ ｄｅｒｍａｔｉｔｉｓ ｗｉｔｈ ｔａｃｒｏｌｉｍｕｓ ｏｉｎｔｍｅｎｔ", Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ａｃａｄｅｍｙ ｏｆ Ｄｅｒｍａｔｏｌｏｇｙ, 2002, Ｖｏｌ．４７， Ｎｏ．６, ｐ．８８１−４
JPN6010028983, ＫＡＮＥＫＵＲＡ，Ｔ． ｅｔ ａｌ, "Ｅｆｆｉｃａｃｙ ｏｆ ｔｏｐｉｃａｌ ｔａｃｒｏｌｉｍｕｓ ｆｏｒ ｔｒｅａｔｉｎｇ ｔｈｅ ｍａｌａｒ ｒａｓｈ ｏｆ ｓｙｓｔｅｍｉｃ ｌｕｐｕｓ ｅｒｙｔｈｅｍａｔｏｓｕｓ", Ｔｈｅ Ｂｒｉｔｉｓｈ ｊｏｕｒｎａｌ ｏｆ ｄｅｒｍａｔｏｌｏｇｙ, 2003, Ｖｏｌ．１４８， Ｎｏ．２, ｐ．３５３−６
JPN6010028984, ＳＣＨＵＳＴＥＲ，Ｃ． ｅｔ ａｌ, "Ｓｕｃｃｅｓｓｆｕｌ ｔｒｅａｔｍｅｎｔ ｏｆ ｒｅｃａｌｃｉｔｒａｎｔ ｃｈｒｏｎｉｃ ａｃｔｉｎｉｃ ｄｅｒｍａｔｉｔｉｓ ｗｉｔｈ ｔａｃｒｏｌｉｍｕｓ", Ｄｅｒｍａｔｏｌｏｇｙ（Ｂａｓｅｌ， Ｓｗｉｔｚｅｒｌａｎｄ）, 2004, Ｖｏｌ．２０９， Ｎｏ．４, ｐ．３２５−８
JPN6010028990, ＴＲＡＮ，Ｃ． ｅｔ ａｌ, "Ｔｏｐｉｃａｌ ｔａｃｒｏｌｉｍｕｓ ｄｅｃｒｅａｓｅｓ ＵＶＢ−ｉｎｄｕｃｅｄ ＤＮＡ ｄａｍａｇｅ ｉｎ ｍｏｕｓｅ ｓｋｉｎ", Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ, 2003, Ｖｏｌ．１２１， Ｎｏ．１
JPN6010028988, ＢＯＲＮＨＯＶＤ，Ｅ．Ｃ． ｅｔ ａｌ, "Ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｍａｃｒｏｌａｃｔａｍｓ ｆｏｒ ｔｏｐｉｃａｌ ｔｒｅａｔｍｅｎｔ ｏｆ ｉｎｆｌａｍｍａｔｏｒｙ ｓｋｉｎ ｄｉｓｅａｓｅｓ", Ｃｕｒｒ Ｏｐｉｎ Ｉｎｖｅｓｔｉｇ Ｄｒｕｇｓ, 2002, Ｖｏｌ．３， Ｎｏ．５, ｐ．７０８−１２
JPN6010028983, ＫＡＮＥＫＵＲＡ，Ｔ． ｅｔ ａｌ, "Ｅｆｆｉｃａｃｙ ｏｆ ｔｏｐｉｃａｌ ｔａｃｒｏｌｉｍｕｓ ｆｏｒ ｔｒｅａｔｉｎｇ ｔｈｅ ｍａｌａｒ ｒａｓｈ ｏｆ ｓｙｓｔｅｍｉｃ ｌｕｐｕｓ ｅｒｙｔｈｅｍａｔｏｓｕｓ", Ｔｈｅ Ｂｒｉｔｉｓｈ ｊｏｕｒｎａｌ ｏｆ ｄｅｒｍａｔｏｌｏｇｙ, 2003, Ｖｏｌ．１４８， Ｎｏ．２, ｐ．３５３−６
JPN6010028984, ＳＣＨＵＳＴＥＲ，Ｃ． ｅｔ ａｌ, "Ｓｕｃｃｅｓｓｆｕｌ ｔｒｅａｔｍｅｎｔ ｏｆ ｒｅｃａｌｃｉｔｒａｎｔ ｃｈｒｏｎｉｃ ａｃｔｉｎｉｃ ｄｅｒｍａｔｉｔｉｓ ｗｉｔｈ ｔａｃｒｏｌｉｍｕｓ", Ｄｅｒｍａｔｏｌｏｇｙ（Ｂａｓｅｌ， Ｓｗｉｔｚｅｒｌａｎｄ）, 2004, Ｖｏｌ．２０９， Ｎｏ．４, ｐ．３２５−８
JPN6010028990, ＴＲＡＮ，Ｃ． ｅｔ ａｌ, "Ｔｏｐｉｃａｌ ｔａｃｒｏｌｉｍｕｓ ｄｅｃｒｅａｓｅｓ ＵＶＢ−ｉｎｄｕｃｅｄ ＤＮＡ ｄａｍａｇｅ ｉｎ ｍｏｕｓｅ ｓｋｉｎ", Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ, 2003, Ｖｏｌ．１２１， Ｎｏ．１
JPN6010028988, ＢＯＲＮＨＯＶＤ，Ｅ．Ｃ． ｅｔ ａｌ, "Ｉｍｍｕｎｏｍｏｄｕｌａｔｏｒｙ ｍａｃｒｏｌａｃｔａｍｓ ｆｏｒ ｔｏｐｉｃａｌ ｔｒｅａｔｍｅｎｔ ｏｆ ｉｎｆｌａｍｍａｔｏｒｙ ｓｋｉｎ ｄｉｓｅａｓｅｓ", Ｃｕｒｒ Ｏｐｉｎ Ｉｎｖｅｓｔｉｇ Ｄｒｕｇｓ, 2002, Ｖｏｌ．３， Ｎｏ．５, ｐ．７０８−１２
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi