Title:
新規のヒドロキシ-6-ヘテロアリールフェナントリジン及び当該化合物を含有する医薬組成物
Document Type and Number:
Japanese Patent JP5193320
Kind Code:
B2
Abstract:
Compounds of formula I
in which
R1 is methoxy,
R2 is methoxy, ethoxy, difluoromethoxy or 2,2-difluoroethoxy,
R3 is hydrogen,
R31 is hydrogen,
R4 is -O-R41, in which
R41 is hydrogen,
R5 is hydrogen,
Har is substituted by R6 and R7, and is pyridinyl, in which
R6 is oxo, and
R7 is methyl,
or an enantiomer, a salt, a N-oxide or a salt of an enantiomer or N-oxide thereof
are novel effective PDE4 inhibitors.
More Like This:
Inventors:
Beate Schmidt
Dieter Flockelzi
Armin Hazelmann
Christoph Zitt
Johannes Barzig
Degenhard Marx
Hans-Peter Cry
Ulrich Kautz
Dieter Flockelzi
Armin Hazelmann
Christoph Zitt
Johannes Barzig
Degenhard Marx
Hans-Peter Cry
Ulrich Kautz
Application Number:
JP2011011310A
Publication Date:
May 08, 2013
Filing Date:
January 21, 2011
Export Citation:
Assignee:
Nycomed GmbH
International Classes:
C07D401/04; A61K31/473; A61P11/00; A61P11/06; A61P11/08; A61P17/00; A61P17/04; A61P17/14; A61P19/02; A61P29/00; A61P37/02; A61P37/08; C07D401/14; C07D405/04; C07D413/04; C07D417/04; C07D417/14; C07D471/04; A61K31/506; A61K31/5377; C07D401/12
Domestic Patent References:
| JP2004504316A | ||||
| JP2000507256A | ||||
| JP2002534507A | ||||
| JP2001510826A |
Foreign References:
| WO2002005616A1 |
Attorney, Agent or Firm:
Takuya Kuno
Toshio Yano
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Toshio Yano
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard