Title:
フェニル安息香酸誘導体、その調製方法、この誘導体を含む医薬品組成物、およびその治療的使用
Document Type and Number:
Japanese Patent JP5078622
Kind Code:
B2
Abstract:
Compounds of the formula (1) in which R1, R2, X, Y and Z are as defined in the description, the processes for the preparation of these compounds, the uses thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, and the pharmaceutical compositions comprising them.
Inventors:
Brunet, Michelle
Adige, Natalie
Guyard-Danglen, Valerie
Contar, Francis
Adige, Natalie
Guyard-Danglen, Valerie
Contar, Francis
Application Number:
JP2007550704A
Publication Date:
November 21, 2012
Filing Date:
December 22, 2005
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07C65/40; A61K31/122; A61K31/341; A61K31/40; A61K31/4192; A61K31/42; A61K31/421; A61K31/4245; A61K31/426; A61K31/427; A61K31/44; A61P3/06; A61P3/10; A61P9/10; C07B37/04; C07B41/02; C07B41/12; C07C51/373; C07C67/03; C07C69/76; C07D207/325; C07D213/30; C07D249/06; C07D261/08; C07D263/32; C07D271/06; C07D277/24; C07D307/68; C07D417/04; C07B61/00
Domestic Patent References:
| JP2005503433A | ||||
| JP2004530668A | ||||
| JP2000510145A |
Foreign References:
| WO2001060796A1 | ||||
| WO2004094363A1 | ||||
| WO2004094382A1 | ||||
| WO2004002939A1 | ||||
| US20040235888 |
Other References:
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Sophie Marquais, Michael Arlt,Aryl-aryl cross coupling on a solid support using zinc organic reagents and palladium catalysis,Tetrahedron Letters,NL,Elsevier B.V.,1996年 7月29日,vol.37, No.31,p.5491-5494
Takeo Sato,Estrogenic biphenyls. VII. Preparation and estrogenic action of methoxyl derivatives of 4-methoxybiphenyl-4'-carboxylic acid,Bulletin of the Chemical Society of Japan,日本,社団法人日本化学会,1959年,vol.32, No.12,p.1292-1294
Scott I. Klein, Mark Czekaj, Charles J. Gardner, Kevin R. Guertin, Daniel L. Cheney, Alfred P. Spada, Scott A. Bolton, Karen Brown, Dennis Colussi, Christopher L. Heran, Suzanne R. Morgan, Robert J. Leadley, Christopher T. Dunwiddie, Mark H. Perrone, Valeria Chu,Identification and Initial Structure-Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa,Journal of Medicinal Chemistry,米国,ACS Publications,1998年 2月12日,vol.41, No.4,p.437-450
Philip J. Hajduk, Jurgen Dinges, Gregory F. Miknis, Megan Merlock, Tim Middleton, Dale J. Kempf, David A. Egan, Karl A. Walter, Terry S. Robins, Suzy B. Shuker, Thomas F. Holzman, Stephen W. Fesik,NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein,Journal of Medicinal Chemistry,米国,ACS Publications,1997年 9月26日,vol.40, No.20,p.3144-3150
Ng. Ph. Buu-Hoi, Louis Petit,Orientation in Friedel-Crafts acylations of 3-chloro-2-methoxybiphenyl,Journal of Organic Chemistry,米国,ACS Publications,1959年 1月,vol.24, No.1,p.39-41
Ponnambalanadar Ananthakrishnanadar, Nagaratnam Kannan,Kinetics of reaction of picryl bromide with substituted biphenyl-4-carboxylate ions,Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry,英国,Royal Sciety of Chemistry,1982年10月,No.10,p.1305-1308
Ponnambalanadar Ananthakrishnanadar, Nagaratnam Kannan,The effects of substituents on the rate of saponification of biphenyl-4-carboxylates,Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry,英国,Royal Sciety of Chemistry,1984年 1月,No.1,p.35-37
Sophie Marquais, Michael Arlt,Aryl-aryl cross coupling on a solid support using zinc organic reagents and palladium catalysis,Tetrahedron Letters,NL,Elsevier B.V.,1996年 7月29日,vol.37, No.31,p.5491-5494
Takeo Sato,Estrogenic biphenyls. VII. Preparation and estrogenic action of methoxyl derivatives of 4-methoxybiphenyl-4'-carboxylic acid,Bulletin of the Chemical Society of Japan,日本,社団法人日本化学会,1959年,vol.32, No.12,p.1292-1294
Scott I. Klein, Mark Czekaj, Charles J. Gardner, Kevin R. Guertin, Daniel L. Cheney, Alfred P. Spada, Scott A. Bolton, Karen Brown, Dennis Colussi, Christopher L. Heran, Suzanne R. Morgan, Robert J. Leadley, Christopher T. Dunwiddie, Mark H. Perrone, Valeria Chu,Identification and Initial Structure-Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa,Journal of Medicinal Chemistry,米国,ACS Publications,1998年 2月12日,vol.41, No.4,p.437-450
Philip J. Hajduk, Jurgen Dinges, Gregory F. Miknis, Megan Merlock, Tim Middleton, Dale J. Kempf, David A. Egan, Karl A. Walter, Terry S. Robins, Suzy B. Shuker, Thomas F. Holzman, Stephen W. Fesik,NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein,Journal of Medicinal Chemistry,米国,ACS Publications,1997年 9月26日,vol.40, No.20,p.3144-3150
Ng. Ph. Buu-Hoi, Louis Petit,Orientation in Friedel-Crafts acylations of 3-chloro-2-methoxybiphenyl,Journal of Organic Chemistry,米国,ACS Publications,1959年 1月,vol.24, No.1,p.39-41
Ponnambalanadar Ananthakrishnanadar, Nagaratnam Kannan,Kinetics of reaction of picryl bromide with substituted biphenyl-4-carboxylate ions,Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry,英国,Royal Sciety of Chemistry,1982年10月,No.10,p.1305-1308
Ponnambalanadar Ananthakrishnanadar, Nagaratnam Kannan,The effects of substituents on the rate of saponification of biphenyl-4-carboxylates,Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry,英国,Royal Sciety of Chemistry,1984年 1月,No.1,p.35-37
Attorney, Agent or Firm:
Akio Miyazaki
Ishibashi Masayuki
Masaaki Ogata
Ishibashi Masayuki
Masaaki Ogata