Title:
A preparing method of a Carboxamidine compound
Document Type and Number:
Japanese Patent JP6221148
Kind Code:
B2
Abstract:
The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.
Inventors:
Foundrick Keith Earl
Gao Joe Joo
Mulder Jason Alan
Patel Nitin Chandra Dee
Zen Shin Jung
Gao Joe Joo
Mulder Jason Alan
Patel Nitin Chandra Dee
Zen Shin Jung
Application Number:
JP2014556643A
Publication Date:
November 01, 2017
Filing Date:
February 07, 2013
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07C259/14; C07C47/24; C07C251/40; C07C271/12
Domestic Patent References:
| JP4253935A | ||||
| JP2013534245A |
Foreign References:
| WO2008050200A1 | ||||
| WO2008117148A1 | ||||
| WO2001074829A1 |
Other References:
VIKTOR BAGUTSKI,FULL CHIRALITY TRANSFER IN THE CONVERSION 以下省略,ANGEWANDTE CHEMIE, INTERNATIONAL EDITION,2010年 7月12日,V49 N30,P5142-5145
STEFAN NAVE,PROTODEBORONATION OF TERTIARY BORONIC ESTERS: 以下省略,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010年12月 8日,V132 N48,P17096-17098
Brown, Herbert C.; Imai, Toshiro; Perumal, P. Thirumali; Singaram, Bakthan,Organoboranes. 41. Reaction of organoboranes with (dichloromethyl)lithium. Scope and limitations. Synthesis of homologated primary and secondary alcohols,Journal of Organic Chemistry ,1985年,50(21),4032-4036
Eastwood, Paul et al.,Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement,Bioorganic & Medicinal Chemistry Letters,2011年,21(21),6253-6257
ZHIHUI WANG,TETRAHEDRON LETTERS,NL,ELSEVIER,2011年 8月23日,V52 N45,P5968-5971
Czekelius, Constantin; Carreira, Erick M.,Convenient transformation of optically active nitroalkanes into chiral aldoximes and nitriles,Angewandte Chemie, International Edition ,2005年,44(4),612-615.
Sonawane, Ravindra P. et al.,Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications,Angewandte Chemie, International Edition,2011年,50(16),3760-3763,and Supporting Info.
FANDRICK,K.R. et al」,Organic Letters,2014年,Vol.16,pp.4360-4363
STEFAN NAVE,PROTODEBORONATION OF TERTIARY BORONIC ESTERS: 以下省略,JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2010年12月 8日,V132 N48,P17096-17098
Brown, Herbert C.; Imai, Toshiro; Perumal, P. Thirumali; Singaram, Bakthan,Organoboranes. 41. Reaction of organoboranes with (dichloromethyl)lithium. Scope and limitations. Synthesis of homologated primary and secondary alcohols,Journal of Organic Chemistry ,1985年,50(21),4032-4036
Eastwood, Paul et al.,Indolin-2-one p38α inhibitors III: Bioisosteric amide replacement,Bioorganic & Medicinal Chemistry Letters,2011年,21(21),6253-6257
ZHIHUI WANG,TETRAHEDRON LETTERS,NL,ELSEVIER,2011年 8月23日,V52 N45,P5968-5971
Czekelius, Constantin; Carreira, Erick M.,Convenient transformation of optically active nitroalkanes into chiral aldoximes and nitriles,Angewandte Chemie, International Edition ,2005年,44(4),612-615.
Sonawane, Ravindra P. et al.,Enantioselective Construction of Quaternary Stereogenic Centers from Tertiary Boronic Esters: Methodology and Applications,Angewandte Chemie, International Edition,2011年,50(16),3760-3763,and Supporting Info.
FANDRICK,K.R. et al」,Organic Letters,2014年,Vol.16,pp.4360-4363
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Takeshi Fujiwara
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Takeshi Fujiwara