Title:
皮膚化粧品及び治療用途を有する水溶性でかつ活性化可能なフェノール誘導体、及び該誘導体の調製方法
Document Type and Number:
Japanese Patent JP5607925
Kind Code:
B2
Abstract:
The invention relates to the preparation of phenolics derivatives by enzymatic condensation of phenolics selected among pyrocatechol or its derivatives including (i) protocatechuic acid and its derivatives, (ii) 3,4-dihydroxycinnamic acid with its trans isomer or caffeic acid and its derivatives, especially hydrocaffeic acid, rosmarinic acid, chlorogenic acid and caffeic acid phenethyl ester, and with its cis-isomer and its derivatives, especially esculin, (iii) dihydroxyphenylglycol, and (iv) members of the flavonoid familly such as taxifolin and fustin (dihydroflavonols), fisetin (a flavonol), eriodictyol (a flavanone), , with the glucose moiety of sucrose. The production of said phenolics derivatives is achieved with a glucosyltransferase (EC 2.4.1.5) obtained from a culture of Leuconostoc species, and more particularly from the culture of Leuconostoc mesenteroides NRRL B-512F. These O-glucosides of selected phenolics are new, have a solubility in water higher than that of their parent polyphenol and have useful applications in cosmetic and pharmaceutical compositions, such as antioxidative, antiviral, antibacterial, immune-stimulating, antiallergic, antihypertensive, antiischemic, antiarrhytmic, antithrombotic, hypocholesterolemic, antilipoperoxidant, hepatoprotective, anti-inflammatory, anticarcinogenic antimutagenic, antineoplastic, anti-thrombotic, and vasodilatory formulations, or in any other field of application. All the more, glucosylated phenolics derivatives objects of the invention can be hydrolyzed by the human natural microbiotes, thus releasing the active part of the phenolic compound upon time during their usage or by an ±-glucosidase (EC 3.2.1.20).
Inventors:
オリオル, Daniel
ナラン, Renault
ロベ, Patrick
Lefebvre, Fabrice
ナラン, Renault
ロベ, Patrick
Lefebvre, Fabrice
Application Number:
JP2009514791A
Publication Date:
October 15, 2014
Filing Date:
June 13, 2007
Export Citation:
Assignee:
Lebra Gen LIBRAGEN
International Classes:
C12P19/56; A61K8/60; A61K31/7034; A61K31/7048; A61K31/706; A61P9/00; A61P17/00; A61P29/00; A61P31/04; A61P35/00; A61P37/02; A61P37/08; A61Q19/00; C07H15/203; C07H15/24; C07H17/02; C07H17/04; C07H17/065; C07H17/07
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukada
Saito a fringe -- happy
Koshiro Tsukada
Saito a fringe -- happy