Title:
プロスタグランジンを調製するためのプロセス及び中間体
Document Type and Number:
Japanese Patent JP5554888
Kind Code:
B2
Abstract:
A method for preparing cyclopentanones or lactones is provided to be useful for preparation of prostagladins, to remove problems such as the long synthesis route and the removal of undesired isomers, and thus achieves a simple and economical synthesis route. The method for preparing a compound of the following formula II having an enantiomer purity higher than 95% e.e.(enantiomeric excess) comprises the steps of: reacting a compound of the following formula IV having an optical purity higher than 90% e.e. with cuprate; and optionally performing a de-protection reaction of the obtained compound to convert P1, P2, or both P1 and P2 into H. In the formulae, Z does not take part in coupling and de-protection reactions and is an optional group acting as a leaving group in reduction/lactonization reactions, R2 is a single bond, C1-4 alkylene or -CH2O- group, R3 is a C1-7-alkyl or aryl or aralkyl unsubstituted or substituted by C1-4 alkyl, halogen or trihalomethyl, X1 and X2 are independently hydrogen or P1 and P2, respectively, wherein P1 and P2 are protective groups for hydroxyl groups which are identical to or different from each other.
Inventors:
A way, the See * イ
イェー, ユ * Chee
イェー, ユ * Chee
Application Number:
JP2007009403A
Publication Date:
July 23, 2014
Filing Date:
January 18, 2007
Export Citation:
Assignee:
チャイロ gate International Ink. CHIROGATE INTERNATIONAL INC.
International Classes:
C07C405/00; A61K31/5575; A61K31/5585; A61P1/00; A61P1/04; A61P7/02; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P15/00; A61P27/02; A61P43/00; C07D307/83; C07F7/18; C07B53/00; C07B61/00
Attorney, Agent or Firm:
Patent business corporation Alga patent firm
Koya Toshio
Toshio Nakajima
Murata Masaki
Hiroto Yamamoto
Koya Toshio
Toshio Nakajima
Murata Masaki
Hiroto Yamamoto