Title:
蛋白質の標識化合物
Document Type and Number:
Japanese Patent JPWO2015125892
Kind Code:
A1
Abstract:
本発明は、一般式（I）[化１](式中、Ｚは[化２]を示す。Y1はN又はCR1を示し、Y2はN又はCR2を示し、Y3はN又はCR3を示し、Y4はN又はCR4を示し、これら式中のR1〜R4のいずれか１つは下記式-(L1)n1-Lg(式中、L1は2価の連結基を示し、n1は0又は1を示し、Lgは蛋白質に対するリガンドを示す)で表す基を示し、R1〜R4の他の3つの基は水素原子又は置換基を示し、R5〜R9のいずれか１つは下記式-(L2)n2-pr(式中、L2は2価の連結基を示し、n2は0又は1を示し、prはプローブを示す)で表す基を示し、R5〜R9の他の4つの基は水素原子又は置換基を示す。）で表される化合物又はその塩を提供する。
Inventors:
Hamaji
Kazuya Matsuo
Marie Masuda
Nishikawa Yuki
Kazuya Matsuo
Marie Masuda
Nishikawa Yuki
Application Number:
JP2016504177A
Publication Date:
March 30, 2017
Filing Date:
February 19, 2015
Export Citation:
Assignee:
Kyoto University
International Classes:
C07D213/82; C07C309/77; C07C309/89; C07D213/89; C07D233/60; C07D241/08; C07D401/12; C07D401/14; C07D475/04; C07D493/10
Other References:
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FILE REGISTRY ON STN, RN 1442631-53-9, ENTERED STN: 01 JUL 2013, JPN7015000678
FILE REGISTRY ON STN, RN 1343408-24-1, ENTERED STN: 09 NOV 2011, JPN7015000679
FILE REGISTRY ON STN, RN 203639-82-1, ENTERED STN: 05 APR 1998, JPN7015000680
OTSUKI, S ET AL.: "Chemical tagging of a drug target using 5-sulfonyl tetrazole", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, JPN6015018266, 2013, pages 1608 - 1611, XP028986046, DOI: doi:10.1016/j.bmcl.2013.01.092
FUJISHIMA, S. ET AL.: "Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Liver Cells", J. AM. CHEM. SOC., vol. 134, JPN6015018267, 2012, pages 3961 - 3964
HUGHES, C. C. ET AL: "Marinopyrrole A Target Elucidation by Acyl Dye Transfer", J. AM. CHEM. SOC., vol. 131, JPN6015018268, 2009, pages 12094 - 12096, XP055221497, DOI: doi:10.1021/ja903149u
FILE REGISTRY ON STN, RN 857435-48-4, ENTERED STN: 28 JUL 2005, JPN7015000677
FILE REGISTRY ON STN, RN 1442631-53-9, ENTERED STN: 01 JUL 2013, JPN7015000678
FILE REGISTRY ON STN, RN 1343408-24-1, ENTERED STN: 09 NOV 2011, JPN7015000679
FILE REGISTRY ON STN, RN 203639-82-1, ENTERED STN: 05 APR 1998, JPN7015000680
OTSUKI, S ET AL.: "Chemical tagging of a drug target using 5-sulfonyl tetrazole", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, JPN6015018266, 2013, pages 1608 - 1611, XP028986046, DOI: doi:10.1016/j.bmcl.2013.01.092
FUJISHIMA, S. ET AL.: "Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Liver Cells", J. AM. CHEM. SOC., vol. 134, JPN6015018267, 2012, pages 3961 - 3964
HUGHES, C. C. ET AL: "Marinopyrrole A Target Elucidation by Acyl Dye Transfer", J. AM. CHEM. SOC., vol. 131, JPN6015018268, 2009, pages 12094 - 12096, XP055221497, DOI: doi:10.1021/ja903149u
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office