Title:
A quinazoline derivative and a manufacturing method for the same
Document Type and Number:
Japanese Patent JP6207752
Kind Code:
B2
Abstract:
The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.
Inventors:
School registration
Vermilion rock
Hu Far East
King tiger garden
Lee's succession
Peng Yu
Zhang Hui
Luo Hung
Hole
Han Yong Shin
Vermilion rock
Hu Far East
King tiger garden
Lee's succession
Peng Yu
Zhang Hui
Luo Hung
Hole
Han Yong Shin
Application Number:
JP2016544710A
Publication Date:
October 04, 2017
Filing Date:
September 28, 2014
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
CENTAURUS BIOPHARMA CO., LTD.
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
CENTAURUS BIOPHARMA CO., LTD.
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.
International Classes:
C07D401/12; A61K31/517; A61K31/5377; A61P35/00; C07D401/14; C07D403/12; C07D405/14
Domestic Patent References:
| JP2010529115A | ||||
| JP2002530386A | ||||
| JP2004516283A | ||||
| JP2007510624A |
Foreign References:
| WO2007055513A1 | ||||
| WO2008002039A1 | ||||
| WO2013042006A1 |
Attorney, Agent or Firm:
Fukami patent office
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