Title:
ノルオキシモルホン化合物の精製方法
Document Type and Number:
Japanese Patent JP5587541
Kind Code:
B2
Abstract:
A process for purifying plant extracts which consist essentially of noroxymorphone compounds and which comprise, as impurities, α,β-unsaturated noroxymorphone compounds, by (a) converting the plant extract or the product of a subsequent stage in the synthesis of a selected noroxymorphone compound in a reaction which converts the hydroxyl groups present in the mixture to leaving groups of the formula —OR2 in which R2 is the introduced radical of the leaving group, (b) these leaving groups are optionally detached again, then (c) the resulting mixture is subjected to a selective hydrogenation, so that a saturated bond is formed in the α,β-position of the unsaturated noroxymorphone compounds and any remaining leaving groups are each converted to a hydroxyl group and then optionally (d) the pure noroxymorphone compound is isolated; processing of the noroxymorphone purified in this way to naltrexone or naloxone or a salt of these compounds or a quaternary derivative of these compounds; pharmaceutical formulations comprising such a compound.
Inventors:
ヴァイグル, Ulich
Cates, a wolf
Fly フェルド, Ilir
Cates, a wolf
Fly フェルド, Ilir
Application Number:
JP2007554413A
Publication Date:
September 10, 2014
Filing Date:
February 09, 2006
Export Citation:
Assignee:
シラグ アーゲー
International Classes:
C07D489/08; A61K31/485; A61P25/36
Attorney, Agent or Firm:
Yusuke Hiraki
Teiji Ishii
Setsu Fujita
Shinji Endo
Teiji Ishii
Setsu Fujita
Shinji Endo