Title:
A remedial medication method of DHE which enables quick relief of migraine while making a side-effects profile into the minimum
Document Type and Number:
Japanese Patent JP6209198
Kind Code:
B2
Abstract:
Pharmaceutical compositions containing dihydroergotamine (DHE) and methods in which DHE is administered to patients for treatment of migraine without side effects or adverse effects are disclosed. Methods for rapid treatment of migraine with DHE are disclosed comprising: dampening the peak plasma concentration (Cmax) and slightly delaying the peak such as to avoid activating the dopaminergic and adrenergic receptors, while achieving sufficient binding to the serotonin receptors to provide relief from migraine symptoms with a timeframe that permits rapid resolution of migraine symptoms. Inhaler devices suitable for the methods are disclosed. Kits for practicing the methods of invention are disclosed.
Inventors:
Robert O. Cook
Stephen B. Shrewsbury
Naby N. Ramadan
Thomas A. Armor
Stephen B. Shrewsbury
Naby N. Ramadan
Thomas A. Armor
Application Number:
JP2015236885A
Publication Date:
October 04, 2017
Filing Date:
December 03, 2015
Export Citation:
Assignee:
Map Pharmaceuticals Incorporated
International Classes:
A61K31/48; A61K9/72; A61K47/06; A61P25/06
Foreign References:
| WO2005025506A1 | ||||
| US20030091513 |
Other References:
SILBERSTEIN,S.D. et al,Headache,2003年,Vol.43, No.2,p.144-66
Attorney, Agent or Firm:
Kawaguchi International Patent Office