Title:
A reversible covalent bond of a functional molecule
Document Type and Number:
Japanese Patent JP5954789
Kind Code:
B2
Abstract:
The present invention relates to the use of a compound of formula (Ia) as a reagent for linking a compound of formula R 1 -H which comprises a first functional moiety of formula F 1 to a second functional moiety of formula F 2
wherein X, X', Y, R 1 , R 2 , R 3 , R 3 ', F 1 and F 2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.
More Like This:
| JP2004531269 | Male contraceptives |
| WO/2014/094799 | UBIQUITIN MOIETIES AS A MEANS FOR PROLONGING SERUM HALF-LIFE |
| WO/2007/096382 | METHOD FOR PRODUCTION OF A TRANSFORMED CELL |
Inventors:
Smith, mark
Cadick, stefan
Baker, James
Chudasama, Vijay
Cadick, stefan
Baker, James
Chudasama, Vijay
Application Number:
JP2012524272A
Publication Date:
July 20, 2016
Filing Date:
August 09, 2010
Export Citation:
Assignee:
UCL Business Public Limited Company
International Classes:
A61K47/48; A61K38/43; A61K39/395; A61K45/00; A61K51/00; C07D207/444; C07D209/52; C07K14/655
Domestic Patent References:
| JP2009504784A |
Other References:
AL-HOLLY, M.M. et al,Synthesis of Glucosylthiomaleimides,Pharmazie,1979年,Vol.34, No.10,p.645-646
佐藤久雄 他,モノクロロマレイン酸ヒドラジド誘導体の合成 メチルチオおよびフェニルチオマレイン酸ヒドラジドの合成とN-メチル誘導体およびO-アシル誘導体の合成,東京医科大学紀要,1985年,No.11,p.1-12
利根川雅実 他,モノクロロマレイン酸ヒドラジド誘導体の合成 2 -メタンチオールによる塩素の置換反応-,東京医科大学紀要,1988年,No.14,p.1-11
SHAUNAK, S. et al,Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge,Bioconjug. Chem.,2007年,Vol.18, No.1,p.61-76
佐藤久雄 他,モノクロロマレイン酸ヒドラジド誘導体の合成 メチルチオおよびフェニルチオマレイン酸ヒドラジドの合成とN-メチル誘導体およびO-アシル誘導体の合成,東京医科大学紀要,1985年,No.11,p.1-12
利根川雅実 他,モノクロロマレイン酸ヒドラジド誘導体の合成 2 -メタンチオールによる塩素の置換反応-,東京医科大学紀要,1988年,No.14,p.1-11
SHAUNAK, S. et al,Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge,Bioconjug. Chem.,2007年,Vol.18, No.1,p.61-76
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki
Junzo Koike
Hirofumi Toma
Previous Patent: Electronic parts, an electricity-receiving device, and an electric supply system
Next Patent: VARIABLE VOLUME PUMP
Next Patent: VARIABLE VOLUME PUMP