The substance which has singularity to human PD-1

Title:

The substance which has singularity to human PD-1

Document Type and Number:

Japanese Patent JP6157574

Kind Code:

B2

Abstract:

The present invention relates to a substance specific to human PD-1 comprising a part that recognizes human PD-1, a part that recognizes a membrane protein in cell membrane of human PD-1-expressing cells, and linkers. Since the substance specific to human PD-1 selectively can recognize human PD-1 and a membrane protein on cell membrane of human PD-1-expressing cells and can transmit inhibitory signal of human PD-1, it is useful for therapy and/or prevention of diseases caused by immunopathy.

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Inventors:

Tasuku Honjo
Shiro Shibayama
Kazuhiko Takeda
Matsuo Masayoshi
Takao Yoshida
Miyamoto Masakazu

Application Number:

JP2015239678A

Publication Date:

July 05, 2017

Filing Date:

December 08, 2015

Export Citation:

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Assignee:

Ono Pharmaceutical Co., Ltd.
Tasuku Honjo

International Classes:

C07K16/46; A61K39/395; A61P37/06; C07K16/28; C12N5/12; C12N15/09; C12N15/13; C12P21/08

Domestic Patent References:

JP2000201678A

Foreign References:

WO2001014557A1
WO2002078731A1

Other References:

Proc. Natl. Acad. Sci. USA.,1993年,Vol.90,pp.6444-6448
Structure,1994年,Vol.2,pp.1217-1226
Journal of immunological methods,1999年,Vol.231,pp.177-189
J.Biol.Chem,,1992年12月 5日,Vol.267,No.34,pp.24223-24229
Protein Engineering,2000年,Vol.13, No.8,pp.583-588

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Masaru Nakajima

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