Title:
the -- the substitution tetrahydroisoquinoline compound as XIA factor inhibitor
Document Type and Number:
Japanese Patent JP6033317
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (IX):
or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.
Inventors:
Michael Jay Owat
Donald Jay P. Pinto
Leon M Smith the Second
Shefari Srivastava
James Earl Court
Donald Jay P. Pinto
Leon M Smith the Second
Shefari Srivastava
James Earl Court
Application Number:
JP2014535894A
Publication Date:
November 30, 2016
Filing Date:
October 12, 2012
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D217/26; A61K31/437; A61K31/4375; A61K31/4545; A61K31/472; A61K31/4725; A61K31/4985; A61K31/5377; A61P7/02; A61P9/00; A61P9/10; A61P29/00; C07D401/10; C07D401/14; C07D413/14; C07D471/04; C07D487/04
Domestic Patent References:
| JP2007501844A | ||||
| JP2010529991A |
Foreign References:
| WO2011100401A1 |
Other References:
TIFELLE NGOUANSAVANH,ANGEWANDTE CHEMIE INTERNATIONAL EDITION,2007年 7月23日,V46 N30,P5775-5778
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Nishino Mitsuru
Nagatoshi Shinagawa
Yasushi Morimoto
Nishino Mitsuru