Title:
【発明の名称】傷ついた組織に対するターゲッティング医薬品剤
Document Type and Number:
Japanese Patent JP2002521044
Kind Code:
A
Abstract:
The present invention provides new compositions and methods to induce therapeutic angiogenesis locally utilizing a collagen binding domain to target an angiogenesis modulating agents. Fusion polypeptides containing a collagen binding domain linked to an angiogenesis modulating agent are provided, as are nucleic acid sequences encoding the fusion polypeptides. Also included are methods for locally altering circulation by administering a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or by administering a nucleic acid sequences encoding the fusion polypeptide. Tissue grafts in which isolated tissue is treated with a fusion polypeptide consisting of a collagen binding domain linked to an angiogenesis modulating agent, or with a nucleic acid sequences encoding the fusion polypeptide are also provided, as are methods of making the grafts.
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Inventors:
Hall Frederick El
Gordon Elrina Em
Starness Bow A
Anderson W French
Gordon Elrina Em
Starness Bow A
Anderson W French
Application Number:
JP2000562049A
Publication Date:
July 16, 2002
Filing Date:
July 30, 1999
Export Citation:
Assignee:
University of Southern California
International Classes:
C12N15/09; A01K67/027; A61K38/00; A61K38/19; A61K38/27; A61K38/43; A61K39/395; A61K47/48; A61L27/00; A61P1/00; A61P1/04; A61P3/10; A61P9/00; A61P19/02; A61P29/00; A61P31/00; A61P35/00; C07K7/06; C07K14/52; C07K14/755; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/62; C12P21/02; C12Q1/02; A61K48/00; (IPC1-7): C12N15/09; A61K38/00; A61K38/27; A61K38/43; A61K39/395; A61K47/48; A61L27/00; A61P1/04; A61P3/10; A61P9/00; A61P29/00; A61P35/00; C07K7/06; C07K14/52; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02
Domestic Patent References:
| JPH08337596A | 1996-12-24 | |||
| JPH08337596A | 1996-12-24 |
Other References:
JPN6009031132, Ｉｖａｎ Ｒｏｉｔｔ、外２名, 免疫学イラストレイテッド（原書第２版）, 19900710, ｐ．３２３−３２５, 南江堂
JPN6009031134, Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ． １９９８ Ｊｕｎ， Ｖｏｌ．９５， Ｎ
JPN6009032481, Ａｎｎａｌｓ ｏｆ ｔｈｅ Ｎｅｗ Ｙｏｒｋ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ． １９９１， Ｖｏｌ．６３６， ｐ．２３３−２５０
JPN6009031136, ＦＥＢＳ ｌｅｔｔｅｒｓ． １９９２， Ｖｏｌ．２９８， Ｎｏ．２−３， ｐ．１２６−１２８
JPN6009031138, Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ ｍｏｌｅｃｕｌａｒ ｍｅｄｉｃｉｎｅ． １９９６， Ｖｏｌ．５８， Ｎｏ．２， ｐ．２２７−２３３
JPN6009031140, Ｅｎｄｏｃｒｉｎｅ ｒｅｖｉｅｗｓ． １９９７， Ｖｏｌ．１８， Ｎｏ．１， ｐ．４−２５
JPN5001017774, Ｈｕｍａｎ ｇｅｎｅ ｔｈｅｒａｐｙ． １９９７， Ｖｏｌ．８， Ｎｏ．１１， ｐ．１３８５−１３９４
JPN6009031134, Ｐｒｏｃｅｅｄｉｎｇｓ ｏｆ ｔｈｅ Ｎａｔｉｏｎａｌ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ ｏｆ ｔｈｅ Ｕｎｉｔｅｄ Ｓｔａｔｅｓ ｏｆ Ａｍｅｒｉｃａ． １９９８ Ｊｕｎ， Ｖｏｌ．９５， Ｎ
JPN6009032481, Ａｎｎａｌｓ ｏｆ ｔｈｅ Ｎｅｗ Ｙｏｒｋ Ａｃａｄｅｍｙ ｏｆ Ｓｃｉｅｎｃｅｓ． １９９１， Ｖｏｌ．６３６， ｐ．２３３−２５０
JPN6009031136, ＦＥＢＳ ｌｅｔｔｅｒｓ． １９９２， Ｖｏｌ．２９８， Ｎｏ．２−３， ｐ．１２６−１２８
JPN6009031138, Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ ｍｏｌｅｃｕｌａｒ ｍｅｄｉｃｉｎｅ． １９９６， Ｖｏｌ．５８， Ｎｏ．２， ｐ．２２７−２３３
JPN6009031140, Ｅｎｄｏｃｒｉｎｅ ｒｅｖｉｅｗｓ． １９９７， Ｖｏｌ．１８， Ｎｏ．１， ｐ．４−２５
JPN5001017774, Ｈｕｍａｎ ｇｅｎｅ ｔｈｅｒａｐｙ． １９９７， Ｖｏｌ．８， Ｎｏ．１１， ｐ．１３８５−１３９４
Attorney, Agent or Firm:
Sakio Ohba (2 outside)