NURRサブファミリーの核転写因子の抑制による疾患に対する治療アプローチ

Japanese Patent JP2004514649

A

Synovial CRH functions in a paracrine manner to induce the nuclear transcription factor NURR1, which is abundantly expressed in the inflammatory cells of both rheumatoid arthritis and psoriatic arthritis synovium. This induction is suppressed by glucocorticoids. The invention is directed to the pivotal role the NURR subfamily of transcription factors plays in modulation of peripheral CRH and CRH-mediated signaling through the CRH-receptor subtype R1alpha, particularly in the inflammatory process in human arthritis.

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Murphy, Evelyn
Connelly, Aura Em.
Fitzgerald, Oliver
Blessihan, barry

JP2001585142A

May 20, 2004

May 11, 2001

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Baylor College of Medicine

A61K31/573; A61K31/7088; A61K35/76; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P17/06; A61P19/02; A61P29/00; A61P37/00; A61P43/00; C07J5/00; C07K14/47; C07K14/705; C07K16/28; C12N15/09; G01N33/50; C12Q1/02; G01N33/15; G01N33/68; A61K38/00; (IPC1-7): A61K45/00; A61K31/573; A61K31/7088; A61K35/76; A61K39/395; A61K48/00; A61P1/00; A61P17/06; A61P19/02; A61P29/00; A61P37/00; A61P43/00; C12Q1/02; G01N33/15; G01N33/50

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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